Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants

Early life microbial colonization and succession is critically important to healthy development with impacts on metabolic and immunologic processes throughout life. A longitudinal prospective cohort was recruited from midwifery practices to include infants born at full term gestation to women with u...

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Bibliographic Details
Published in:Scientific reports 2017-11, Vol.7 (1), p.16527-9, Article 16527
Main Authors: Stearns, Jennifer C, Simioni, Julia, Gunn, Elizabeth, McDonald, Helen, Holloway, Alison C, Thabane, Lehana, Mousseau, Andrea, Schertzer, Jonathan D, Ratcliffe, Elyanne M, Rossi, Laura, Surette, Michael G, Morrison, Katherine M, Hutton, Eileen K
Format: Article
Language:English
Subjects:
Antibiotics
Bifidobacterium
Childbirth & labor
Colonization
Digestive system
Gestation
Health risk assessment
Infants
Intestinal microflora
Microbiota
Prophylaxis
rRNA
Streptococcus infections
Vagina
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Summary:Early life microbial colonization and succession is critically important to healthy development with impacts on metabolic and immunologic processes throughout life. A longitudinal prospective cohort was recruited from midwifery practices to include infants born at full term gestation to women with uncomplicated pregnancies. Here we compare bacterial community succession in infants born vaginally, with no exposure to antibiotics (n = 53), with infants who were exposed to intrapartum antibiotic prophylaxis (IAP) for Group B Streptococcus (GBS; n = 14), and infants born by C-section (n = 7). Molecular profiles  of the 16 S rRNA genes indicate that there is a delay in the expansion of Bifidobacterium, which was the dominate infant gut colonizer, over the first 12 weeks and a persistence of Escherichia when IAP for GBS exposure is present during vaginal labour. Longer duration of IAP exposure increased the magnitude of the effect on Bifidobacterium populations, suggesting a longer delay in microbial community maturation. As with prior studies, we found altered gut colonisation following C-section that included a notable lack of Bacteroidetes. This study found that exposure of infants to IAP for GBS during vaginal birth affected aspects of gut microbial ecology that, although dramatic at early time points, disappeared by 12 weeks of age in most infants.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-16606-9