Acute Localized Exanthematous Pustulosis (ALEP): Review of Literature with Report of Case Caused by Amoxicillin-Clavulanic Acid

Acute localized exanthematous pustulosis (ALEP) is a localized form of acute generalized exanthematous pustulosis, characterized by acute onset of multiple nonfollicular, pinhead-sized, sterile pustules following drug administration. Antibiotics, especially β-lactams and macrolides, have been implic...

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Bibliographic Details
Published in:Dermatology and therapy 2017-12, Vol.7 (4), p.563-570
Main Authors: Villani, Alessia, Baldo, Antonello, De Fata Salvatores, Gaia, Desiato, Vincenzo, Ayala, Fabio, Donadio, Carlo
Format: Article
Language:English
Subjects:
Antibiotics
Case Report
Dermatology
Internal Medicine
Medicine
Medicine & Public Health
Oral and Maxillofacial Surgery
Penicillin
Plastic Surgery
Quality of Life Research
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Summary:Acute localized exanthematous pustulosis (ALEP) is a localized form of acute generalized exanthematous pustulosis, characterized by acute onset of multiple nonfollicular, pinhead-sized, sterile pustules following drug administration. Antibiotics, especially β-lactams and macrolides, have been implicated in the majority of cases, although eruption after nonsteroidal antiinflammatory drugs and many other medications has also been reported. Skin reaction arises quickly within a few hours, resolving rapidly within a few days without treatment, and it is usually accompanied by fever and neutrophilic leukocytosis. We report herein all cases of ALEP described in literature, adding the case of a 35-year-old woman admitted to our hospital with outbreak of erythematous pustules on her face, neck, and chest after amoxicillin–clavulanic acid treatment.
ISSN:2193-8210
2190-9172
DOI:10.1007/s13555-017-0206-1