Cardiac Remodeling in Response to 1 Year of Intensive Endurance Training

BACKGROUND—It is unclear whether, and to what extent, the striking cardiac morphological manifestations of endurance athletes are a result of exercise training or a genetically determined characteristic of talented athletes. We hypothesized that prolonged and intensive endurance training in previous...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2014-12, Vol.130 (24), p.2152-2161
Main Authors: Arbab-Zadeh, Armin, Perhonen, Merja, Howden, Erin, Peshock, Ronald M, Zhang, Rong, Adams-Huet, Beverly, Haykowsky, Mark J, Levine, Benjamin D
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood and lymphatic vessels
Cardiac Catheterization
Cardiac Output - physiology
Cardiology. Vascular system
Cross-Sectional Studies
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Exercise - physiology
Female
Follow-Up Studies
Heart Ventricles - anatomy & histology
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Oxygen Consumption - physiology
Physical Endurance - physiology
Stroke Volume - physiology
Time Factors
Treatment Outcome
Ventricular Function - physiology
Ventricular Remodeling - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND—It is unclear whether, and to what extent, the striking cardiac morphological manifestations of endurance athletes are a result of exercise training or a genetically determined characteristic of talented athletes. We hypothesized that prolonged and intensive endurance training in previously sedentary healthy young individuals could induce cardiac remodeling similar to that observed cross-sectionally in elite endurance athletes. METHODS AND RESULTS—Twelve previously sedentary subjects (aged 29±6 years; 7 men and 5 women) trained progressively and intensively for 12 months such that they could compete in a marathon. Magnetic resonance images for assessment of right and left ventricular mass and volumes were obtained at baseline and after 3, 6, 9, and 12 months of training. Maximum oxygen uptake ((Equation is included in full-text article.)max) and cardiac output at rest and during exercise (C2H2 rebreathing) were measured at the same time periods. Pulmonary artery catheterization was performed before and after 1 year of training, and pressure-volume and Starling curves were constructed during decreases (lower body negative pressure) and increases (saline infusion) in cardiac volume. Mean (Equation is included in full-text article.)max rose from 40.3±1.6 to 48.7±2.5 mL/kg per minute after 1 year (P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.114.010775