Rescue case of low birth weight infant with acute hepatic failure

We report a case involving a rescued low birth weight infant（LBWI） with acute liver failure. Case: The patient was 1594 g and 323/7 gestational wk at birth. At the age of 11 d, she developed acute liver failure due to gestational alloimmune liver disease. Exchange transfusion and high-dose gamma glo...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2017-10, Vol.23 (40), p.7337-7342
Main Authors: Okada, Noriki, Sanada, Yukihiro, Urahashi, Taizen, Ihara, Yoshiyuki, Yamada, Naoya, Hirata, Yuta, Katano, Takumi, Ushijima, Kentaro, Otomo, Shinya, Fujita, Shujiro, Mizuta, Koichi
Format: Article
Language:English
Subjects:
Biopsy
Case Report
Enteral Nutrition
Exchange Transfusion, Whole Blood
Female
gamma-Globulins - therapeutic use
Graft Rejection - drug therapy
Hemochromatosis - blood
Hemochromatosis - complications
Hemochromatosis - therapy
Humans
Immunosuppression - methods
Infant
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Intra-Abdominal Hypertension - etiology
Intra-Abdominal Hypertension - therapy
Liver - pathology
Liver - surgery
Liver Failure, Acute - blood
Liver Failure, Acute - etiology
Liver Failure, Acute - pathology
Liver Failure, Acute - therapy
Liver Transplantation - adverse effects
Liver Transplantation - methods
Living Donors
Respiratory Insufficiency - etiology
Respiratory Insufficiency - therapy
Treatment Outcome
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Summary:We report a case involving a rescued low birth weight infant（LBWI） with acute liver failure. Case: The patient was 1594 g and 323/7 gestational wk at birth. At the age of 11 d, she developed acute liver failure due to gestational alloimmune liver disease. Exchange transfusion and high-dose gamma globulin therapy were initiated, and body weight increased with enteral nutrition. Exchange transfusion was performed a total of 33 times prior to living donor liver transplantation（LDLT）. Her liver dysfunction could not be treated by medications alone. At 55 d old and a body weight of 2946 g, she underwent LDLT using an S2 monosegment graft from her mother. Three years have passed with no reports of intellectual disability or liver dysfunction. LBWIs with acute liver failure may be rescued by LDLT after body weight has increased to over 2500 g.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v23.i40.7337