Anti-protein and anti-bacterial behavior of amphiphilic silicones

Silicones with improved water-driven surface hydrophilicity and anti-biofouling behavior were achieved when bulk-modified with poly(ethylene oxide) (PEO) -silane amphiphiles of varying siloxane tether length: α-(EtO) Si-(CH ) -oligodimethylsiloxane - -poly(ethylene oxide) -OCH ( = 0, 4, 13, 17, 24,...

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Published in:Polymer chemistry 2017-09, Vol.8 (34), p.5239-5251
Main Authors: Hawkins, Melissa L, Schott, Samantha S, Grigoryan, Bagrat, Rufin, Marc A, Ngo, Bryan Khai D, Vanderwal, Lyndsi, Stafslien, Shane J, Grunlan, Melissa A
Format: Article
Language:English
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Summary:Silicones with improved water-driven surface hydrophilicity and anti-biofouling behavior were achieved when bulk-modified with poly(ethylene oxide) (PEO) -silane amphiphiles of varying siloxane tether length: α-(EtO) Si-(CH ) -oligodimethylsiloxane - -poly(ethylene oxide) -OCH ( = 0, 4, 13, 17, 24, and 30). A PEO -silane [α-(EtO) Si-(CH ) -PEO -OCH ] served as a conventional PEO-silane control. To examine anti-biofouling behavior in the absence versus presence of water-driven surface restructuring, the amphiphiles and control were surface-grafted onto silicon wafers and used to bulk-modify a medical-grade silicone, respectively. While the surface-grafted PEO-control exhibited superior protein resistance, it failed to appreciably restructure to the surface-water interface of bulk-modified silicone and thus led to poor protein resistance. In contrast, the PEO-silane amphiphiles, while less protein-resistant when surface-grafted onto silicon wafers, rapidly and substantially restructured in bulk-modified silicone, exhibiting superior hydrophilicity and protein resistance. A reduction of biofilm for several strains of bacteria and a fungus was observed for silicones modified with PEO-silane amphiphiles. Longer siloxane tethers maintained surface restructuring and protein resistance while displaying the added benefit of increased transparency.
ISSN:1759-9954
1759-9962
DOI:10.1039/c7py00944e