Striatal Dopamine D2/D3 Receptor Availability Varies Across Smoking Status

To assess how tobacco smoking status affects baseline dopamine D2/D3 (D2R) receptor availability and methylphenidate-induced dopamine (DA) release, we retrospectively analyzed D2R availability measures of 8 current smokers, 10 ex-smokers, and 18 nonsmokers who were scanned with positron emission tom...

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Bibliographic Details
Published in:Neuropsychopharmacology (New York, N.Y.) N.Y.), 2017-11, Vol.42 (12), p.2325-2332
Main Authors: Wiers, Corinde E, Cabrera, Elizabeth A, Tomasi, Dardo, Wong, Christopher T, Demiral, Şükrü B, Kim, Sung Won, Wang, Gene-Jack, Volkow, Nora D
Format: Article
Language:English
Subjects:
Adult
Aggression
Aggressive behavior
Availability
Caudate Nucleus - diagnostic imaging
Caudate Nucleus - metabolism
Dopamine
Dopamine D2 receptors
Dopamine D3 receptors
Female
Health risk assessment
Humans
Longitudinal studies
Male
Methylphenidate
Neostriatum
Original
Personality Assessment
Positron emission tomography
Positron-Emission Tomography - trends
Protein Binding - physiology
Putamen
Putamen - diagnostic imaging
Putamen - metabolism
Raclopride
Receptors, Dopamine D2 - metabolism
Receptors, Dopamine D3 - metabolism
Retrospective Studies
Smoking
Smoking - metabolism
Smoking - psychology
Smoking - trends
Tobacco
Tobacco smoking
Ventral Striatum - diagnostic imaging
Ventral Striatum - metabolism
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Summary:To assess how tobacco smoking status affects baseline dopamine D2/D3 (D2R) receptor availability and methylphenidate-induced dopamine (DA) release, we retrospectively analyzed D2R availability measures of 8 current smokers, 10 ex-smokers, and 18 nonsmokers who were scanned with positron emission tomography and [ C]raclopride, after administration of an injection of placebo or 0.5 mg/kg i.v. methylphenidate. There was a significant effect of smoking status on baseline striatal D2R availability; with current smokers showing lower striatal D2R availability compared with nonsmokers (caudate, putamen, and ventral striatum) and with ex-smokers (caudate and putamen). Baseline striatal D2R did not differ between nonsmokers and ex-smokers. The effect of smoking status on methylphenidate-induced DA release tended to be lower in smokers but the difference was not significant (p=0.08). For behavioral measures, current smokers showed significantly higher aggression scores compared with both nonsmokers and ex-smokers. These results suggest that with abstinence ex-smokers may recover from low striatal D2R availability and from increased behavioral aggression seen in active smokers. However, longitudinal studies are needed to assess this within abstaining smokers.
ISSN:0893-133X
1740-634X
DOI:10.1038/npp.2017.131