Volumetry of the dominant intraprostatic tumour lesion: intersequence and interobserver differences on multiparametric MRI

To establish the interobserver reproducibility of tumour volumetry on individual multiparametric (mp) prostate MRI sequences, validate measurements with histology and determine whether functional to morphological volume ratios reflect Gleason score. 41 males with prostate cancer treated with prostat...

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Bibliographic Details
Published in:British journal of radiology 2017-03, Vol.90 (1071), p.20160416-20160416
Main Authors: Harvey, Hugh, Orton, Matthew R, Morgan, Veronica A, Parker, Chris, Dearnaley, David, Fisher, Cyril, deSouza, Nandita M
Format: Article
Language:English
Subjects:
Aged
Contrast Media
Diffusion Magnetic Resonance Imaging - methods
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Male
Neoplasm Grading
Observer Variation
Prostate - diagnostic imaging
Prostate - pathology
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - pathology
Reproducibility of Results
Retrospective Studies
Technical/Instrumental
Tumor Burden
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Summary:To establish the interobserver reproducibility of tumour volumetry on individual multiparametric (mp) prostate MRI sequences, validate measurements with histology and determine whether functional to morphological volume ratios reflect Gleason score. 41 males with prostate cancer treated with prostatectomy (Cohort 1) or radical radiotherapy (Cohort 2), who had pre-treatment mpMRI [T weighted (T2W) MRI, diffusion-weighted (DW)-MRI and dynamic contrast-enhanced (DCE)-MRI], were studied retrospectively. Dominant intraprostatic lesions (DIPLs) were manually delineated on each sequence and volumes were compared between observers (n = 40 analyzable) and with radical prostatectomy (n = 20). Volume ratios of DW-MRI and DCE-MRI to T2W MRI were documented and compared between Gleason grade 3 + 3, 3 + 4 and 4 + 3 or greater categories. Limits of agreement of DIPL volumes between observers were: T2W MRI 0.9, -1.1 cm , DW-MRI 1.3, -1.7 cm and DCE-MRI 0.74, -0.89 cm . In Cohort 1, T2W volumes overestimated fixed specimen histological volumes (+33% Observer 1, +16% Observer 2); DW- and DCE-MRI underestimated histological volume, the latter markedly so (-32% Observer 1, -79% Observer 2). Differences between T2W, DW- and DCE-MRI volumes were significant (p 
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr.20160416