Superoxide Dismutase‐Loaded Porous Polymersomes as Highly Efficient Antioxidants for Treating Neuropathic Pain

A highly efficient antioxidant is developed by encapsulating superoxide dismutase (SOD) within the aqueous interior of porous polymersomes. The porous polymersomes provide a permeable membrane that allows free superoxide radicals to pass into the aqueous interior and interact with the encapsulated a...

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Bibliographic Details
Published in:Advanced healthcare materials 2017-09, Vol.6 (17), p.n/a
Main Authors: Kartha, Sonia, Yan, Lesan, Weisshaar, Christine L., Ita, Meagan E., Shuvaev, Vladimir V., Muzykantov, Vladimir R., Tsourkas, Andrew, Winkelstein, Beth A., Cheng, Zhiliang
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - pharmacology
Antioxidants - therapeutic use
Compression
Encapsulation
Enzymes
Free radicals
In vivo methods and tests
Male
Neuralgia
Neuralgia - drug therapy
Neuralgia - pathology
neuropathic pain
Pain
Pain Threshold
Polymers - chemistry
Porosity
porous polymersomes
Radiculopathy - drug therapy
Radiculopathy - pathology
Rats
Superoxide dismutase
Superoxide Dismutase - metabolism
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Summary:A highly efficient antioxidant is developed by encapsulating superoxide dismutase (SOD) within the aqueous interior of porous polymersomes. The porous polymersomes provide a permeable membrane that allows free superoxide radicals to pass into the aqueous interior and interact with the encapsulated antioxidant enzyme SOD. In vivo studies in the rat demonstrate that administration of SOD‐encapsulated porous polymersomes can prevent neuropathic pain after nerve root compression more effectively than treatment with free antioxidant enzyme alone. Highly efficient antioxidants based on superoxide dismutase (SOD)‐loaded porous polymersomes are developed for treating neuropathic pain. The SOD‐loaded porous polymersomes are highly permeable to superoxide radical, while retaining the antioxidant enzyme within their aqueous interiors. Administration of the antioxidant porous polymersomes following a painful nerve root compression is substantially more effective in preventing the onset of pain in rats than comparable or higher doses of free SOD alone.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201700500