Rapid Selection Response for Contextual Fear Conditioning in a Cross Between C57BL/6J and A/J: Behavioral, QTL and Gene Expression Analysis

We used short-term selection to produce outbred mouse lines with differences in contextual fear conditioning. Within two generations of selection all low selected mice were homozygous for the recessive tyr c allele and showed the corresponding albino coat color. Freezing differed in the high and low...

Full description

Saved in:
Bibliographic Details
Published in:Behavior genetics 2008-05, Vol.38 (3), p.277-291
Main Authors: Ponder, Christine A., Huded, Chetan P., Munoz, Michaelanne B., Gulden, Forrest O., Gilliam, T. Conrad, Palmer, Abraham A.
Format: Article
Language:English
Subjects:
Albinism
Alleles
Amygdala - metabolism
Animals
Behavioral Science and Psychology
Clinical Psychology
Conditioning (Psychology)
Fear
Gene expression
Gene Expression Profiling
Genes, Recessive
Health Psychology
Hippocampus - metabolism
Homozygote
Laboratory animals
Mice
Mice, Inbred C57BL
Models, Genetic
Neurosciences
Oligonucleotide Array Sequence Analysis
Original Paper
Psychology
Public Health
Quantitative Trait Loci
Quantitative Trait, Heritable
Selection, Genetic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We used short-term selection to produce outbred mouse lines with differences in contextual fear conditioning. Within two generations of selection all low selected mice were homozygous for the recessive tyr c allele and showed the corresponding albino coat color. Freezing differed in the high and low selected lines across a range of parameters. We identified several QTLs for the selection response, including a highly significant QTL at the tyr locus ( p  
ISSN:0001-8244
1573-3297
DOI:10.1007/s10519-008-9203-6