Pseudomonas aeruginosa Clinical Isolates in Nepal Coproducing Metallo-β-Lactamases and 16S rRNA Methyltransferases

A total of 11 multidrug-resistant clinical isolates were obtained in Nepal. Four of these isolates harbored genes encoding one or more carbapenemases (DIM-1, NDM-1, and/or VIM-2), and five harbored genes encoding a 16S rRNA methyltransferase (RmtB4 or RmtF2). A novel RmtF variant, RmtF2, had a subst...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2017-09, Vol.61 (9)
Main Authors: Tada, Tatsuya, Shimada, Kayo, Satou, Kazuhito, Hirano, Takashi, Pokhrel, Bharat M, Sherchand, Jeevan B, Kirikae, Teruo
Format: Article
Language:English
Subjects:
Bacterial Proteins
Bacterial Proteins - biosynthesis
Bacterial Proteins - genetics
beta-Lactam Resistance
beta-Lactam Resistance - genetics
beta-Lactamases
beta-Lactamases - biosynthesis
beta-Lactamases - genetics
beta-Lactams - pharmacology
Drug Resistance, Multiple, Bacterial - genetics
Epidemiology and Surveillance
Genome, Bacterial - genetics
Humans
Methyltransferases
Methyltransferases - biosynthesis
Methyltransferases - genetics
Nepal
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - genetics
Pseudomonas aeruginosa - isolation & purification
Pseudomonas aeruginosa - metabolism
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Summary:A total of 11 multidrug-resistant clinical isolates were obtained in Nepal. Four of these isolates harbored genes encoding one or more carbapenemases (DIM-1, NDM-1, and/or VIM-2), and five harbored genes encoding a 16S rRNA methyltransferase (RmtB4 or RmtF2). A novel RmtF variant, RmtF2, had a substitution (K65E) compared with the same gene in RmtF. To our knowledge, this is the first report describing carbapenemase- and 16S rRNA methyltransferase-coproducing clinical isolates in Nepal.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00694-17