Early hypoactivity of hippocampal rhythms during epileptogenesis after prolonged febrile seizures in freely-moving rats

Prospective and experimental studies have shown that individuals with early-life complex/prolonged febrile seizures （FSs） have a high incidence of temporal lobe epilepsy during adulthood, revealing a close relationship between FSs and epilepsy. However, little is known about how epileptogenesis deve...

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Bibliographic Details
Published in:Neuroscience bulletin 2015-06, Vol.31 (3), p.297-306
Main Authors: Feng, Bo, Tang, Yang-Shun, Chen, Bin, Xu, Zheng-Hao, Wang, Yi, Wu, Deng-Chang, Zhao, Hua-Wei, Zhang, Shi-Hong, Chen, Zhong
Format: Article
Language:English
Subjects:
Anatomy
Anesthesiology
Animals
Biomedical and Life Sciences
Biomedicine
Brain Waves
Electroencephalography
Hippocampus - pathology
Hippocampus - physiopathology
Human Physiology
Neurology
Neurons - pathology
Neurons - physiology
Neurosciences
Original
Original Article
Pain Medicine
Rats
Rats, Sprague-Dawley
Seizures, Febrile - pathology
Seizures, Febrile - physiopathology
大鼠
惊厥
早期阶段
海马
生后
癫痫
移动
高热
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Summary:Prospective and experimental studies have shown that individuals with early-life complex/prolonged febrile seizures （FSs） have a high incidence of temporal lobe epilepsy during adulthood, revealing a close relationship between FSs and epilepsy. However, little is known about how epileptogenesis develops after FSs. The present study was designed to investigate acquired seizure susceptibility and analyze local field potentials during the latent period after FSs. We found that the seizure susceptibility decreased in 35-day- old （P35） FS rats but increased in P60 FS rats. Consistently, hippocampal electroencephalogram （EEG） power in every band was decreased at P35 but increased at P60 in FS rats. Our results provide direct evidence for hypoactivity but not hyperactivity during the early phase of the latent period, displaying a broad decrease in hippocampal rhythms. These characteristic EEG changes can be a useful biomarker for the early diagnosis of epileptogenesis induced by FSs.
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-014-1524-2