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Neuronal autophagy in cerebral ischemia
Autophagy has evolved as a conserved process for the bulk degradation and recycling of cytosolic components, such as long-lived proteins and organelles. In neurons, autophagy is important for homeostasis and protein quality control and is maintained at relatively low levels under normal conditions,...
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Published in: | Neuroscience bulletin 2012-10, Vol.28 (5), p.658-666 |
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creator | Xu, Feng Gu, Jin-Hua Qin, Zheng-Hong |
description | Autophagy has evolved as a conserved process for the bulk degradation and recycling of cytosolic components, such as long-lived proteins and organelles. In neurons, autophagy is important for homeostasis and protein quality control and is maintained at relatively low levels under normal conditions, while it is upregulated in response to pathophysiological conditions, such as cerebral ischemic injury. However, the role of autophagy is more complex. It depends on age or brain maturity, region, severity of insult, and the stage of ischemia. Whether autophagy plays a beneficial or a detrimental role in cerebral ischemia depends on various pathological conditions. In this review, we elucidate the role of neuronal autophagy in cerebral ischemia. |
doi_str_mv | 10.1007/s12264-012-1268-9 |
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In this review, we elucidate the role of neuronal autophagy in cerebral ischemia.</description><subject>Anatomy</subject><subject>Anesthesiology</subject><subject>Animals</subject><subject>Apoptosis - physiology</subject><subject>Autophagy - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Ischemia - metabolism</subject><subject>Brain Ischemia - pathology</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Neurology</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Neurosciences</subject><subject>Pain Medicine</subject><subject>Review</subject><subject>体内平衡</subject><subject>生理条件</subject><subject>神经细胞</subject><subject>缺血性脑损伤</subject><subject>脑缺血</subject><subject>自噬作用</subject><subject>蛋白质</subject><subject>质量控制</subject><issn>1673-7067</issn><issn>1995-8218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPAyEUhYnR2Pr4AW5MXelmlAvMhdmYmMZX0uhG14RhmHaadmihY9J_L01roxvZQLjnHA4fIRdAb4FSeReBMRQZBZYBQ5UVB6QPRZFnioE6TGeUPJMUZY-cxDilFKnk4pj0GCtQ5YXok-s31wXfmtnAdCu_mJjxetC0A-uCK0O6baKduHljzshRbWbRne_2U_L59PgxfMlG78-vw4dRZgWqVYZKcCNKqLDIVVUjVWicY9QyKXOODm1dW5lXxinJbG2BC6hEyUugOShAfkrut7mLrpy7yrp2lWroRWjmJqy1N43-O2mbiR77L53nCAWjKeBmFxD8snNxpefpD242M63zXdSQlkLGmUxS2Ept8DEGV--fAao3gPUWsE6A9QawLpLn8ne_veOHaBKwrSCmUTt2QU99FxLg-G_q1a7JxLfjZfLtgwVXEoEJ_g1qd5EL</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Xu, Feng</creator><creator>Gu, Jin-Hua</creator><creator>Qin, Zheng-Hong</creator><general>Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121001</creationdate><title>Neuronal autophagy in cerebral ischemia</title><author>Xu, Feng ; Gu, Jin-Hua ; Qin, Zheng-Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-6843a4b1d6958df6086aee20c277536e6cffc75dae872cfc1341d4b3b10518163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anatomy</topic><topic>Anesthesiology</topic><topic>Animals</topic><topic>Apoptosis - physiology</topic><topic>Autophagy - physiology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Ischemia - metabolism</topic><topic>Brain Ischemia - pathology</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Neurology</topic><topic>Neurons - metabolism</topic><topic>Neurons - pathology</topic><topic>Neurosciences</topic><topic>Pain Medicine</topic><topic>Review</topic><topic>体内平衡</topic><topic>生理条件</topic><topic>神经细胞</topic><topic>缺血性脑损伤</topic><topic>脑缺血</topic><topic>自噬作用</topic><topic>蛋白质</topic><topic>质量控制</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Feng</creatorcontrib><creatorcontrib>Gu, Jin-Hua</creatorcontrib><creatorcontrib>Qin, Zheng-Hong</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Feng</au><au>Gu, Jin-Hua</au><au>Qin, Zheng-Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuronal autophagy in cerebral ischemia</atitle><jtitle>Neuroscience bulletin</jtitle><stitle>Neurosci. Bull</stitle><addtitle>Neuroscience Bulletin</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>28</volume><issue>5</issue><spage>658</spage><epage>666</epage><pages>658-666</pages><issn>1673-7067</issn><eissn>1995-8218</eissn><notes>Feng Xu , Jin-Hua Gu, Zheng-Hong Qin ( 1. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China; 2. Department of Pharmacology, Nantong University School of Medicine, Nantong 226001, China; 3. Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharma-ceutical Science, Suzhou 215123, China)</notes><notes>Autophagy has evolved as a conserved process for the bulk degradation and recycling of cytosolic components, such as long-lived proteins and organelles. In neurons, autophagy is important for homeostasis and protein quality control and is maintained at relatively low levels under normal conditions, while it is upregulated in response to pathophysiological conditions, such as cerebral ischemic injury. However, the role of autophagy is more complex. It depends on age or brain maturity, region, severity of insult, and the stage of ischemia. Whether autophagy plays a beneficial or a detrimental role in cerebral ischemia depends on various pathological conditions. In this review, we elucidate the role of neuronal autophagy in cerebral ischemia.</notes><notes>autophagy; cerebral ischemia; neuron; apoptosis; necrosis</notes><notes>31-1975/R</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><abstract>Autophagy has evolved as a conserved process for the bulk degradation and recycling of cytosolic components, such as long-lived proteins and organelles. In neurons, autophagy is important for homeostasis and protein quality control and is maintained at relatively low levels under normal conditions, while it is upregulated in response to pathophysiological conditions, such as cerebral ischemic injury. However, the role of autophagy is more complex. It depends on age or brain maturity, region, severity of insult, and the stage of ischemia. Whether autophagy plays a beneficial or a detrimental role in cerebral ischemia depends on various pathological conditions. In this review, we elucidate the role of neuronal autophagy in cerebral ischemia.</abstract><cop>Heidelberg</cop><pub>Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences</pub><pmid>22968594</pmid><doi>10.1007/s12264-012-1268-9</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Anatomy Anesthesiology Animals Apoptosis - physiology Autophagy - physiology Biomedical and Life Sciences Biomedicine Brain Ischemia - metabolism Brain Ischemia - pathology Human Physiology Humans Neurology Neurons - metabolism Neurons - pathology Neurosciences Pain Medicine Review 体内平衡 生理条件 神经细胞 缺血性脑损伤 脑缺血 自噬作用 蛋白质 质量控制 |
title | Neuronal autophagy in cerebral ischemia |
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