Neuronal autophagy in cerebral ischemia

Autophagy has evolved as a conserved process for the bulk degradation and recycling of cytosolic components, such as long-lived proteins and organelles. In neurons, autophagy is important for homeostasis and protein quality control and is maintained at relatively low levels under normal conditions,...

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Bibliographic Details
Published in:Neuroscience bulletin 2012-10, Vol.28 (5), p.658-666
Main Authors: Xu, Feng, Gu, Jin-Hua, Qin, Zheng-Hong
Format: Article
Language:English
Subjects:
Anatomy
Anesthesiology
Animals
Apoptosis - physiology
Autophagy - physiology
Biomedical and Life Sciences
Biomedicine
Brain Ischemia - metabolism
Brain Ischemia - pathology
Human Physiology
Humans
Neurology
Neurons - metabolism
Neurons - pathology
Neurosciences
Pain Medicine
Review
体内平衡
生理条件
神经细胞
缺血性脑损伤
脑缺血
自噬作用
蛋白质
质量控制
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Summary:Autophagy has evolved as a conserved process for the bulk degradation and recycling of cytosolic components, such as long-lived proteins and organelles. In neurons, autophagy is important for homeostasis and protein quality control and is maintained at relatively low levels under normal conditions, while it is upregulated in response to pathophysiological conditions, such as cerebral ischemic injury. However, the role of autophagy is more complex. It depends on age or brain maturity, region, severity of insult, and the stage of ischemia. Whether autophagy plays a beneficial or a detrimental role in cerebral ischemia depends on various pathological conditions. In this review, we elucidate the role of neuronal autophagy in cerebral ischemia.
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-012-1268-9