The three dimensional structure of sheep liver 6‐phosphogluconate dehydrogenase at 2.6 A resolution

The three‐dimensional structure of sheep liver 6‐phosphogluconate dehydrogenase has been determined at 2.6 A resolution by X‐ray crystallographic studies. The amino acid sequence of the enzyme is now known and can be fitted to a modified electron density map. Use of 6 A electron density maps and the...

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Bibliographic Details
Published in:The EMBO journal 1983, Vol.2 (6), p.1009-1014
Main Authors: Adams, M.J., Archibald, I.G., Bugg, C.E., Carne, A., Gover, S., Helliwell, J.R., Pickersgill, R.W., White, S.W.
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Electrons
Liver - enzymology
Phosphogluconate Dehydrogenase - metabolism
Protein Conformation
Sheep
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Summary:The three‐dimensional structure of sheep liver 6‐phosphogluconate dehydrogenase has been determined at 2.6 A resolution by X‐ray crystallographic studies. The amino acid sequence of the enzyme is now known and can be fitted to a modified electron density map. Use of 6 A electron density maps and the results of chemical modification experiments allows description of the active site and identification of residues which may be implicated in the binding of co‐enzyme and substrate.
ISSN:0261-4189
1460-2075
DOI:10.1002/j.1460-2075.1983.tb01535.x