An Autopsy Case of Fulminant Hepatitis in a Patient with Multiple Sclerosis Treated by Interferon-Beta-1a

A 44-year-old woman with multiple sclerosis (MS) receiving interferon (IFN)-beta-1a treatment was admitted to a local hospital for severe icterus and liver injury. She was transferred to our university hospital because fulminant hepatitis (FH) was suspected. She was diagnosed with acute-type FH base...

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Bibliographic Details
Published in:Internal Medicine 2017/07/15, Vol.56(14), pp.1897-1901
Main Authors: Yamazaki, Yuichi, Suzuki, Aya, Hirayanagi, Kimitoshi, Tsukagoshi, Yusuke, Uehara, Ryota, Horiguchi, Kazuhiko, Ohyama, Tatsuya, Tomaru, Takuya, Horiguchi, Norio, Nobusawa, Sumihito, Ikota, Hayato, Sato, Ken, Kakizaki, Satoru, Kusano, Motoyasu, Ikeda, Yoshio, Yokoo, Hideaki, Yamada, Masanobu
Format: Article
Language:English
Subjects:
Adult
Autopsies
Autopsy
Case Report
Coma
Female
fulminant hepatitis
Hepatitis
Humans
Interferon
Interferon beta-1a - adverse effects
Interferon beta-1a - therapeutic use
interferon-beta-1a
Internal medicine
Liver
Liver diseases
Liver Failure, Acute - etiology
Medical personnel
Multiple sclerosis
Multiple Sclerosis - drug therapy
β-Interferon
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Summary:A 44-year-old woman with multiple sclerosis (MS) receiving interferon (IFN)-beta-1a treatment was admitted to a local hospital for severe icterus and liver injury. She was transferred to our university hospital because fulminant hepatitis (FH) was suspected. She was diagnosed with acute-type FH based on hepatic coma, severe liver injury and liver failure, and she received plasma exchange and continuous hemodiafiltration therapy. On hospital day 6, she died from liver failure despite intensive care. An autopsy revealed histological findings consistent with FH. Physicians should monitor the hepatic function of MS patients receiving IFN-beta-1a treatment, as serious events can occur in rare cases.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.56.7980