Colorectal cancer screening: An updated review of the available options

Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. However, colon cancer incidence and mortality is declining over the past decade owing to adoption of effective screening programs. Nevertheless, in some parts of the world, CRC incidence and mortality remain on the...

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Bibliographic Details
Published in:	World journal of gastroenterology : WJG 2017-07, Vol.23 (28), p.5086-5096
Main Authors:	Issa, Iyad A, Noureddine, Malak
Format:	Article
Language:	eng
Subjects:	Colonoscopy - economics Colorectal Neoplasms - diagnosis Colorectal Neoplasms - economics Colorectal Neoplasms - epidemiology Colorectal Neoplasms - prevention & control Cost-Benefit Analysis Early Detection of Cancer - economics Early Detection of Cancer - methods Early Detection of Cancer - standards Guideline Adherence Health Care Costs Humans Incidence Mass Screening - economics Mass Screening - methods Mass Screening - standards Occult Blood Review Risk Assessment
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Summary:	Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. However, colon cancer incidence and mortality is declining over the past decade owing to adoption of effective screening programs. Nevertheless, in some parts of the world, CRC incidence and mortality remain on the rise, likely due to factors including "westernized" diet, lifestyle, and lack of health-care infrastructure and resources. Participation and adherence to different national screening programs remain obstacles limiting the achievement of screening goals. Different modalities are available ranging from stool based tests to radiology and endoscopy with varying sensitivity and specificity. However, the availability of these tests is limited to areas with high economic resources. Recently, FDA approved a blood-based test (Epi procolon ) for CRC screening. This blood based test may serve to increase the participation and adherence rates. Hence, leading to increase in colon cancer detection and prevention. This article will discuss various CRC screening tests with a particular focus on the data regarding the new approved blood test. Finally, we will propose an algorithm for a simple cost-effective CRC screening program.
ISSN:	1007-9327 2219-2840