Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment

Maternal immune activation (MIA) during pregnancy has been linked to an increased risk of developing psychiatric pathologies in later life. This link may be bridged by a defective microglial phenotype in the offspring induced by MIA, as microglia have key roles in the development and maintenance of...

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Published in:	Translational psychiatry 2017-05, Vol.7 (5), p.e1120-e1120
Main Authors:	Mattei, D, Ivanov, A, Ferrai, C, Jordan, P, Guneykaya, D, Buonfiglioli, A, Schaafsma, W, Przanowski, P, Deuther-Conrad, W, Brust, P, Hesse, S, Patt, M, Sabri, O, Ross, T L, Eggen, B J L, Boddeke, E W G M, Kaminska, B, Beule, D, Pombo, A, Kettenmann, H, Wolf, S A
Format:	Article
Language:	eng
Subjects:	Adult Children - psychology Alzheimer Disease - drug therapy Alzheimer Disease - genetics Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Behavior, Animal - drug effects Disease Models, Animal Female Humans Immune System Phenomena - drug effects Immune System Phenomena - physiology Mice Mice, Inbred C57BL - immunology Microglia - drug effects Microglia - metabolism Minocycline - administration & dosage Minocycline - pharmacology Original Phagocytosis - immunology Pregnancy Schizophrenia - drug therapy Schizophrenia - genetics Synaptic Transmission - physiology Transcriptome - genetics
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