Intrinsic radiolabeling of Titanium-45 using mesoporous silica nanoparticles

Titanium-45 （4STi） with a three-hour half-life （t1/2=3.08 h）, low maximum positron energy and high positron emission branching ratio, is a suitable positron emission tomography （PET） isotope whose potential has not yet been fully explored. Complicated radiochemistry and rapid hydrolysis continue to...

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Bibliographic Details
Published in:	Acta pharmacologica Sinica 2017-06, Vol.38 (6), p.907-913
Main Authors:	Chen, Feng, Valdovinos, Hector F, Hernandez, Reinier, Goel, Shreya, Barnhart, Todd E, Cai, Weibo
Format:	Article
Language:	eng
Subjects:	Animals Female Isotope Labeling Lewis酸 Mammary Neoplasms, Experimental - diagnosis Mice Mice, Inbred BALB C Nanoparticles - chemistry Original Particle Size Porosity Positron-Emission Tomography Radioisotopes - chemistry Silicon Dioxide - chemistry Surface Properties Titanium - chemistry 乳腺肿瘤二氧化介孔标记技术正电子发射断层扫描生物医学应用硅纳米颗粒
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Summary:	Titanium-45 （4STi） with a three-hour half-life （t1/2=3.08 h）, low maximum positron energy and high positron emission branching ratio, is a suitable positron emission tomography （PET） isotope whose potential has not yet been fully explored. Complicated radiochemistry and rapid hydrolysis continue to be major challenges to the development of 4STi compounds based on a traditional chelator-based radiolabeling strategy. In this study we introduced an intrinsic （or chelator-free） radiolabeling technique for the successful labeling of 45Ti using mesoporous silica nanoparticle （MSN）. We synthesized uniform MSN with an average particle size of -150 nm in diameter. The intrinsic 4STi-labeling was accomplished through strong interactions between 4~Ti （hard Lewis acid） and hard oxygen donors （hard Lewis bases）, the deprotonated silanol groups （-Si-O-） from the outer surface and inner meso-channels of MSN. In vivo tumor-targeted PET imaging of as-developed PEGytated [45Ti]MSN was further demonstrated in the 4T1 murine breast tumor-bearing mice. This MSN- based intrinsic radiolabeling strategy could open up new possibilities and speed up the biomedical applications of 4STi in the future.
ISSN:	1671-4083 1745-7254