Imaging three-dimensional innervation zone distribution in muscles from M-wave recordings

Objective. To localize neuromuscular junctions in skeletal muscles in vivo which is of great importance in understanding, diagnosing and managing of neuromuscular disorders. Approach. A three-dimensional global innervation zone imaging technique was developed to characterize the global distribution...

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Bibliographic Details
Published in:Journal of neural engineering 2017-06, Vol.14 (3), p.036011-036011
Main Authors: Zhang, Chuan, Peng, Yun, Liu, Yang, Li, Sheng, Zhou, Ping, Rymer, William Zev, Zhang, Yingchun
Format: Article
Language:English
Subjects:
Adult
Algorithms
Body Surface Potential Mapping - methods
botulinum neurotoxin injection
electrical source imaging
Electromyography - methods
Evoked Potentials, Motor - physiology
Female
Humans
Imaging, Three-Dimensional - methods
innervation zone
M-wave
Male
Muscle, Skeletal - innervation
Muscle, Skeletal - physiology
Neuromuscular Junction - anatomy & histology
Neuromuscular Junction - physiopathology
neuromuscular junctions
Reproducibility of Results
Sensitivity and Specificity
spasticity
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Summary:Objective. To localize neuromuscular junctions in skeletal muscles in vivo which is of great importance in understanding, diagnosing and managing of neuromuscular disorders. Approach. A three-dimensional global innervation zone imaging technique was developed to characterize the global distribution of innervation zones, as an indication of the location and features of neuromuscular junctions, using electrically evoked high-density surface electromyogram recordings. Main results. The performance of the technique was evaluated in the biceps brachii of six intact human subjects. The geometric centers of the distributions of the reconstructed innervation zones were determined with a mean distance of 9.4  ±  1.4 cm from the reference plane, situated at the medial epicondyle of the humerus. A mean depth was calculated as 1.5  ±  0.3 cm from the geometric centers to the closed points over the skin. The results are consistent with those reported in previous histology studies. It was also found that the volumes and distributions of the reconstructed innervation zones changed as the stimulation intensities increased until the supramaximal muscle response was achieved. Significance. Results have demonstrated the high performance of the proposed imaging technique in noninvasively imaging global distributions of the innervation zones in the three-dimensional muscle space in vivo, and the feasibility of its clinical applications, such as guiding botulinum toxin injections in spasticity management, or in early diagnosis of neurodegenerative progression of amyotrophic lateral sclerosis.
ISSN:1741-2560
1741-2552
DOI:10.1088/1741-2552/aa65dd