Marginal bone loss around non-submerged implants is associated with salivary microbiome during bone healing

Marginal bone loss during bone healing exists around non-submerged dental implants. The aim of this study was to identify therelationship between different degrees of marginal bone loss during bone healing and the salivary microbiome. One hundredpatients were recruited, and marginal bone loss around...

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Bibliographic Details
Published in:International journal of oral science 2017-06, Vol.9 (2), p.95-103
Main Authors: Duan, Xiao-Bo, Wu, Ting-Xi, Guo, Yu-Chen, Zhou, Xue-Dong, Lei, Yi-Ling, Xu, Xin, Mo, An-Chun, Wang, Yong-Yue, Yuan, Quan
Format: Article
Language:English
Subjects:
Abundance
Adolescent
Adult
Alveolar Bone Loss - diagnostic imaging
Alveolar Bone Loss - microbiology
bone
Bone healing
Bone implants
Bone loss
Bones
China
Computed tomography
Cone-Beam Computed Tomography
dental
Dental Implants
Dental Plaque Index
Dental prosthetics
Dental research
Dental restorative materials
Dentistry
Female
Hormone replacement therapy
Humans
illumina
implant
loss
Male
marginal
microbiome
Microbiota
Middle Aged
oral
Original
peri-implantitis
Periodontal Index
Periodontics
Polymerase Chain Reaction
Saliva
Saliva - microbiology
sequencing
Severity of Illness Index
Studies
Taxonomy
Transplants & implants
Wound Healing - physiology
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Description
Summary:Marginal bone loss during bone healing exists around non-submerged dental implants. The aim of this study was to identify therelationship between different degrees of marginal bone loss during bone healing and the salivary microbiome. One hundredpatients were recruited, and marginal bone loss around their implants was measured using cone beam computed tomographyduring a 3-month healing period. The patients were divided into three groups according to the severity of marginal bone loss.Saliva samples were collected from all subjected and were analysed using 16S MiSeq sequencing. Although the overall structureof the microbial community was not dramatically altered, the relative abundance of several taxonomic groups noticeablychanged. The abundance of species in the phyla Spirochaeta and Synergistetes increased significantly as the bone loss becamemore severe. Species within the genus Treponema also exhibited increased abundance, whereas Veillonella, Haemophilus andLeptotrichia exhibited reduced abundances, in groups with more bone loss. Porphyromonasgingivalis, Treponemadenticola andStreptococcus intermedius were significantly more abundant in the moderate group and/or severe group. The severity of marginalbone loss around the non-submerged implant was associated with dissimilar taxonomic compositions. An increased severity ofmarginal bone loss was related to increased proportions of periodontal pathogenic species. These data suggest a potential role ofmicrobes in the progression of marginal bone loss during bone healing.
ISSN:1674-2818
2049-3169
DOI:10.1038/ijos.2017.18