How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?

Cytomegalovirus (CMV) is an important pathogen for both clinical and population settings. There is a growing body of research implicating CMV in multiple health outcomes across the life course. At the same time, there is mounting evidence that individuals living in poverty are more likely to be expo...

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Bibliographic Details
Published in:GeroScience 2017-06, Vol.39 (3), p.261-271
Main Authors: Aiello, Allison E., Chiu, Yen-Ling, Frasca, Daniela
Format: Article
Language:English
Subjects:
Aging
Autoimmune diseases
Autoimmunity
Biomedical and Life Sciences
Cell Biology
Chronic Disease - epidemiology
Congresses as Topic
Cytomegalovirus
Cytomegalovirus - immunology
Cytomegalovirus Infections - epidemiology
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - prevention & control
Cytomegalovirus Vaccines - administration & dosage
Cytomegalovirus Vaccines - immunology
Diabetes mellitus
Evidence-Based Medicine
Geriatrics/Gerontology
Humans
Immune response
Life Sciences
Molecular Medicine
Poverty
Public health
Risk Factors
Social interactions
United States - epidemiology
Vaccination
Vaccination - methods
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Summary:Cytomegalovirus (CMV) is an important pathogen for both clinical and population settings. There is a growing body of research implicating CMV in multiple health outcomes across the life course. At the same time, there is mounting evidence that individuals living in poverty are more likely to be exposed to CMV and more likely to experience many of the chronic conditions for which CMV has been implicated. Further research on the causal role of CMV for health and well-being is needed. However, the strong evidence implicating CMV in type 2 diabetes, autoimmunity, cancer, cardiovascular disease, vaccination, and age-related alterations in immune function warrants clinical and public health action. This imperative is even higher among individuals living in socioeconomically disadvantaged settings and those exposed to high levels of chronic psychosocial stress.
ISSN:2509-2715
2509-2723
DOI:10.1007/s11357-017-9983-9