Energy metabolic pathways control the fate and function of myeloid immune cells

Review of how the cellular metabolism of myeloid cells dictates the immune response, and therapeutic implications in cancer and other inflammatory conditions. The past decade has seen a significant interest in investigating the intracellular metabolism of cells of the immune system. This has increas...

Full description

Saved in:
Bibliographic Details
Published in:Journal of leukocyte biology 2017-08, Vol.102 (2), p.369-380
Main Authors: Al‐Khami, Amir A., Rodriguez, Paulo C., Ochoa, Augusto C.
Format: Article
Language:English
Subjects:
Adaptive immunity
Animals
Cancer
Cell Differentiation - immunology
dendritic cell
Humans
Immune response
Immune system
Immunity
Inflammation
macrophage
MDSC
Metabolic Networks and Pathways - immunology
Metabolic pathways
Metabolism
Myeloid cells
Myeloid Cells - cytology
Myeloid Cells - immunology
Myeloid Cells - metabolism
neutrophil
Reviews
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Review of how the cellular metabolism of myeloid cells dictates the immune response, and therapeutic implications in cancer and other inflammatory conditions. The past decade has seen a significant interest in investigating the intracellular metabolism of cells of the immune system. This has increased the realization that immune cells endure metabolic reprogramming upon responding to pathogen‐derived or inflammatory signals. More importantly, not only does this metabolic switch provide for the bioenergetic and biosynthetic demands but also it, in a highly specific manner, determines the cellular fate and function. In this review, we discuss the metabolic aspects that regulate the differentiation and function of myeloid cells, pivotal for both innate and adaptive immunity. The manipulation of these pathways can alter the function of these cells and therefore, could provide novel therapeutic approaches in cancer and other chronic inflammatory conditions.
ISSN:0741-5400
1938-3673
DOI:10.1189/jlb.1VMR1216-535R