Understanding the determinants of health-related quality of life in rheumatoid arthritis-associated interstitial lung disease

Abstract Rationale Health-related quality of life (HRQL) is impaired among patients with interstitial lung disease (ILD). Little is understood about HRQL in specific subtypes of ILD. Objectives The aim of this study was to characterize and identify clinical determinants of HRQL among patients with r...

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Bibliographic Details
Published in:Respiratory medicine 2017-06, Vol.127, p.1-6
Main Authors: Natalini, Jake G., M.D, Swigris, Jeff J., D.O., M.S, Morisset, Julie, M.D, Elicker, Brett M., M.D, Jones, Kirk D., M.D, Fischer, Aryeh, M.D, Collard, Harold R., M.D, Lee, Joyce S., M.D
Format: Article
Language:English
Subjects:
Aged
Arthritis
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - psychology
Carbon monoxide
Carbon Monoxide - metabolism
Cohort Studies
Dyspnea
Dyspnea - diagnosis
Dyspnea - physiopathology
Dyspnea - psychology
Emotions
Fatigue
Female
Fibrosis
Forced Expiratory Volume - physiology
Health
Humans
Identification methods
Idiopathic pulmonary fibrosis
Idiopathic Pulmonary Fibrosis - complications
Idiopathic Pulmonary Fibrosis - physiopathology
Idiopathic Pulmonary Fibrosis - psychology
Interstitial lung disease
Longitudinal Studies
Lung - physiopathology
Lung diseases
Lung Diseases, Interstitial - complications
Lung Diseases, Interstitial - physiopathology
Lung Diseases, Interstitial - psychology
Male
Middle Aged
Pain
Patients
Pulmonary fibrosis
Pulmonary/Respiratory
Quality of life
Quality of Life - psychology
Questionnaires
Regression analysis
Respiration
Respiratory function
Respiratory Function Tests - methods
Rheumatoid arthritis
Severity of Illness Index
Society
Stiffness
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Summary:Abstract Rationale Health-related quality of life (HRQL) is impaired among patients with interstitial lung disease (ILD). Little is understood about HRQL in specific subtypes of ILD. Objectives The aim of this study was to characterize and identify clinical determinants of HRQL among patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and compare them to patients with idiopathic pulmonary fibrosis (IPF). Methods We identified patients with a diagnosis of RA-ILD and IPF from an ongoing longitudinal cohort of ILD patients. HRQL was measured at their baseline visit using the Short Form Health Survey (SF-36), versions 1 and 2. Regression models were used to characterize and understand the relationship between selected baseline clinical covariates, the physical component score (PCS) and mental component score (MCS) of the SF-36. Measurements and main results RA-ILD patients (n = 50) were more likely to be younger and female compared to IPF patients (n = 50). After controlling for age and pulmonary function, RA-ILD patients had a lower HRQL compared to IPF patients, as measured by the PCS ( P  = 0.03), with significant differences in two of four PCS domains – bodily pain ( P  
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2017.04.002