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Age-Related Changes in the Composition of Gut Bifidobacterium Species
Bifidobacteria are one of the major components in human microbiota that are suggested to function in maintaining human health. The colonization and cell number of Bifidobacterium species in human intestine vary with ageing. However, sequential changes of Bifidobacterium species ranging from newborns...
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Published in: | Current microbiology 2017-08, Vol.74 (8), p.987-995 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Bifidobacteria are one of the major components in human microbiota that are suggested to function in maintaining human health. The colonization and cell number of
Bifidobacterium
species in human intestine vary with ageing. However, sequential changes of
Bifidobacterium
species ranging from newborns to centenarians remain unresolved. Here, we investigated the gut compositional changes of
Bifidobacterium
species over a wide range of ages. Faecal samples of 441 healthy Japanese subjects between the ages of 0 and 104 years were analysed using real-time PCR with species-specific primers.
B. longum
group was widely detected from newborns to centenarians, with the highest detection rate.
B. breve
was detected in approximately 70% of children under 3 years old.
B. adolescentis
and
B. catenulatum
groups were predominant after weaning.
B. bifidum
was detected at almost all ages. The detection rate of
B. dentium
was higher in the elderly than in other ages.
B. animalis
ssp.
lactis
was detected in 11.4% of the subjects and their ages were restricted.
B. gallinarum
goup was detected in only nine subjects, while
B. minimum
and
B. mongoliense
were undetected at any age. The presence of certain
Bifidobacterium
groups was associated with significantly higher numbers of other
Bifidobacterium
species/subspecies. Inter-species correlations were found among each species, exception for
B. animalis
ssp.
lactis
. These results revealed the patterns and transition points with respect to compositional changes of
Bifidobacterium
species that occur with ageing, and the findings indicate that there may be symbiotic associations between some of these species in the gut microbiota. |
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ISSN: | 0343-8651 1432-0991 |
DOI: | 10.1007/s00284-017-1272-4 |