Metabolic response of porcine colon explants to in vitro infection by Brachyspira hyodysenteriae: a leap into disease pathophysiology

Introduction Swine dysentery caused by Brachyspira hyodysenteriae is a production limiting disease in pig farming. Currently antimicrobial therapy is the only treatment and control method available. Objective The aim of this study was to characterize the metabolic response of porcine colon explants...

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Bibliographic Details
Published in:Metabolomics 2017-07, Vol.13 (7), p.83-83, Article 83
Main Authors: Welle, Thijs, Hoekstra, Anna T., Daemen, Ineke A. J. J. M., Berkers, Celia R., Costa, Matheus O.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Citrulline
Colon
Developmental Biology
Dysentery
Explants
Gangrene
Gene expression
Infections
Inflammation
Interleukin 1
Life Sciences
Livestock
Metabolic response
Metabolism
Molecular Medicine
Necrosis
Short Communication
Spirochetes
Swine
Swine dysentery
Waterborne diseases
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Summary:Introduction Swine dysentery caused by Brachyspira hyodysenteriae is a production limiting disease in pig farming. Currently antimicrobial therapy is the only treatment and control method available. Objective The aim of this study was to characterize the metabolic response of porcine colon explants to infection by B. hyodysenteriae . Methods Porcine colon explants exposed to B. hyodysenteriae were analyzed for histopathological, metabolic and pro-inflammatory gene expression changes. Results Significant epithelial necrosis, increased levels of l -citrulline and IL-1α were observed on explants infected with B. hyodysenteriae . Conclusions The spirochete induces necrosis in vitro likely through an inflammatory process mediated by IL-1α and NO.
ISSN:1573-3882
1573-3890
DOI:10.1007/s11306-017-1219-6