The prognostic value of pre-diagnosis health-related quality of life on survival: a prospective cohort study of older Americans with lung cancer

Purpose Health-related quality of life (HRQOL) after cancer diagnosis is prognostic for overall survival (OS). However, no studies have assessed if HRQOL before diagnosis is predictive for OS. The objective of this study was to determine the association between pre-lung cancer diagnosis HRQOL and OS...

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Bibliographic Details
Published in:Quality of life research 2017-07, Vol.26 (7), p.1703-1712
Main Authors: Pinheiro, Laura C., Zagar, Timothy M., Reeve, Bryce B.
Format: Article
Language:English
Subjects:
Activities of daily living
Activities of Daily Living - psychology
Aged
Aged, 80 and over
Aging
CLINICAL AND POLICY APPLICATIONS
Cohort analysis
Cohort Studies
Female
Humans
Lung cancer
Lung Neoplasms - mortality
Lung Neoplasms - psychology
Male
Medical diagnosis
Medical prognosis
Medicine
Medicine & Public Health
Older people
Prognosis
Prospective Studies
Public Health
Quality of life
Quality of Life - psychology
Quality of Life Research
Sociology
Survival Analysis
Survivor
United States
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Summary:Purpose Health-related quality of life (HRQOL) after cancer diagnosis is prognostic for overall survival (OS). However, no studies have assessed if HRQOL before diagnosis is predictive for OS. The objective of this study was to determine the association between pre-lung cancer diagnosis HRQOL and OS. Methods Our prospective cohort study used surveillance, epidemiology, and end results linked to the Medicare Health Outcomes Survey. We included 6290 individuals 65 years or older diagnosed with incident lung cancer from 1998 to 2013. We assessed the prognostic value of (1) short-form 36 summary component and domain-specific scores, (2) activities of daily living (ADL), and (3) two global HRQOL questions. Cox-proportional hazards models were used to examine associations between HRQOL and OS, adjusting for demographics, comorbid conditions, and clinical characteristics. Results Worse pre-diagnosis HRQOL was significantly associated with greater risk of death across HRQOL measures. An above average physical or mental component summary score was associated with 16 and 24% decreases in the hazard of death, respectively (p
ISSN:0962-9343
1573-2649
DOI:10.1007/s11136-017-1515-7