Type IV Pilin, PilA, Contributes to Adherence of Burkholderia pseudomallei and Virulence In Vivo

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murin...

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Bibliographic Details
Published in:Infection and Immunity 2005-02, Vol.73 (2), p.1260-1264
Main Authors: Essex-Lopresti, Angela E, Boddey, Justin A, Thomas, Richard, Smith, Martin P, Hartley, M. Gill, Atkins, Timothy, Brown, Nat F, Tsang, Chuk Hai, Peak, Ian R. A, Hill, Jim, Beacham, Ifor R, Titball, Richard W
Format: Article
Language:English
Subjects:
Animals
Bacterial Adhesion - genetics
Bacterial Adhesion - physiology
Bacteriology
Biological and medical sciences
Burkholderia pseudomallei
Burkholderia pseudomallei - genetics
Burkholderia pseudomallei - metabolism
Burkholderia pseudomallei - pathogenicity
Caenorhabditis elegans - metabolism
Caenorhabditis elegans - microbiology
Cells, Cultured
Epithelial Cells - metabolism
Epithelial Cells - microbiology
Fimbriae Proteins - metabolism
Fimbriae, Bacterial - genetics
Fimbriae, Bacterial - metabolism
Fundamental and applied biological sciences. Psychology
Humans
Mice
Microbiology
Miscellaneous
Molecular Pathogenesis
Time Factors
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Summary:The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.73.2.1260-1264.2005