Virulence factors associated with Coagulase Negative Staphylococci isolated from human infections

Infections caused by commensal organisms by changing to infectious life style generate much challenge to the current treatment strategies. Coagulase Negative Staphylococci (CoNS) are one of them, with their coexisting biofilm forming and multiple antibiotic resistance properties form important agent...

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Bibliographic Details
Published in:3 Biotech 2017-06, Vol.7 (2), p.140-10, Article 140
Main Authors: Soumya, K. R., Philip, Suja, Sugathan, Sheela, Mathew, Jyothis, Radhakrishnan, E. K.
Format: Article
Language:English
Subjects:
Agriculture
Antibiotic resistance
Antibiotics
Biofilms
Bioinformatics
Biomaterials
Biotechnology
Cancer Research
Carbohydrates
Chemical composition
Chemistry
Chemistry and Materials Science
Coagulase
Drug resistance
Gene frequency
Genotypes
Hospitals
Multidrug resistance
Nosocomial infection
Nosocomial infections
Organic chemistry
Original
Original Article
Proteins
Stem Cells
Virulence
Virulence factors
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Summary:Infections caused by commensal organisms by changing to infectious life style generate much challenge to the current treatment strategies. Coagulase Negative Staphylococci (CoNS) are one of them, with their coexisting biofilm forming and multiple antibiotic resistance properties form important agents of nosocomial infection. To evaluate species distribution, biofilm formation, and antibiogram, CoNS isolates from various clinical samples were isolated. The presence of biofilm and associated genes icaAB, aap, atlE, embp, bhp, and fbe in CoNS was screened by PCR. The biofilm chemical composition and its correlation with the genotypes were also analysed. Staphylococcus epidermidis (59%) was found to be the most prevalent CoNS species. Most of the CoNS isolates harboring biofilm gene showed carbohydrate-protein-eDNA biofilm, whereas carbohydrate-protein biofilms were also observed. High percentage of multiple drug resistance, and biofilm gene frequency among these CoNS isolates point towards the need of periodic surveillance as CoNS are recently identified to cause difficult to treat infections.
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-017-0753-2