Breast cancer mortality in Copenhagen after introduction of mammography screening: cohort study

Objectives To evaluate the effect on breast cancer mortality during the first 10 years of the mammography service screening programme that was introduced in Copenhagen in 1991. Design Cohort study. Setting The mammography service screening programme in Copenhagen, Denmark. Participants All women eve...

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Bibliographic Details
Published in:BMJ 2005-01, Vol.330 (7485), p.220-222
Main Authors: Olsen, Anne Helene, Njor, Sisse H, Vejborg, Ilse, Schwartz, Walter, Dalgaard, Peter, Jensen, Maj-Britt, Tange, Ulla Brix, Blichert-Toft, Mogens, Rank, Fritz, Mouridsen, Henning, Lynge, Elsebeth
Format: Article
Language:English
Subjects:
Age groups
Aged
Biological and medical sciences
Breast cancer
Breast Neoplasms - mortality
Breast Neoplasms - prevention & control
Cancer screening
Cohort Studies
Confidence interval
Control groups
Denmark - epidemiology
Female
Follow-Up Studies
General aspects
Genital system. Mammary gland
Gynecology. Andrology. Obstetrics
Humans
Investigative techniques, diagnostic techniques (general aspects)
Mammary gland diseases
Mammography
Mammography - mortality
Mass Screening - methods
Mass Screening - mortality
Medical sciences
Medical screening
Middle Aged
Mortality
Population control
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Regression Analysis
Risk Factors
Selection bias
Tumors
Citations: Items that cite this one
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Summary:Objectives To evaluate the effect on breast cancer mortality during the first 10 years of the mammography service screening programme that was introduced in Copenhagen in 1991. Design Cohort study. Setting The mammography service screening programme in Copenhagen, Denmark. Participants All women ever invited to mammography screening in the first 10 years of the programme. Historical, national, and historical national control groups were used. Main outcome measures The main outcome measure was breast cancer mortality. We compared breast cancer mortality in the study group with rates in the control groups, adjusting for age, time period, and region. Results Breast cancer mortality in the screening period was reduced by 25% (relative risk 0.75, 95% confidence interval 0.63 to 0.89) compared with what we would expect in the absence of screening. For women actually participating in screening, breast cancer mortality was reduced by 37%. Conclusions In the Copenhagen programme, breast cancer mortality was reduced without severe negative side effects for the participants.
ISSN:0959-8138
0959-8146
1468-5833
1756-1833
DOI:10.1136/bmj.38313.639236.82