Novel functions of circulating Klotho

Abstract A significant portion of the key biological functions of αKlotho (αKL) and its cognate ligand Fibroblast growth factor-23 (FGF23) have been revealed through the study of rare diseases of mineral metabolism. These findings have far reaching implications for common disorders such as chronic k...

Full description

Saved in:
Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2017-07, Vol.100, p.36-40
Main Authors: Hum, Julia M, O'Bryan, Linda, Smith, Rosamund C, White, Kenneth E
Format: Article
Language:English
Subjects:
Animals
cKL
FGF23
Fibroblast Growth Factors - genetics
Fibroblast Growth Factors - metabolism
Glucuronidase - genetics
Glucuronidase - metabolism
Humans
Hyperphosphatemia
Hypophosphatemia
Mice
Orthopedics
Parathyroid Hormone - genetics
Parathyroid Hormone - metabolism
Phosphate
Phosphates - metabolism
Renal Insufficiency, Chronic - genetics
Renal Insufficiency, Chronic - metabolism
Vascular calcification
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract A significant portion of the key biological functions of αKlotho (αKL) and its cognate ligand Fibroblast growth factor-23 (FGF23) have been revealed through the study of rare diseases of mineral metabolism. These findings have far reaching implications for common disorders such as chronic kidney disease-mineral bone disorder (CKD-MBD). αKL's predominant effect on mineral homeostasis is through its actions in the kidney as a co-receptor for FGF23, however emerging data has shed light on its capacity to act as a circulating factor through the cleavage of the transmembrane form of αKL (‘mKL’) to produce ‘cleaved KL’ or ‘cKL’. This review summarizes new findings from studies using extended delivery of cKL to mouse models with phenotypes reflecting those arising in CKD-MBD.
ISSN:8756-3282
1873-2763
DOI:10.1016/j.bone.2016.11.025