Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies

Abstract Objective To explore the association between migraine and risk of ischaemic stroke. Design Systematic review and meta-analysis. Data sources Observational studies published between 1966 and June 2004 (identified through Medline and Embase) that examined the association between migraine and...

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Bibliographic Details
Published in:	BMJ 2005-01, Vol.330 (7482), p.63-65
Main Authors:	Etminan, Mahyar, Takkouche, Bahi, Isorna, Francisco Caamaño, Samii, Ali
Format:	Article
Language:	eng
Subjects:	Adolescent Adult Age Distribution Aged Aged, 80 and over Biological and medical sciences Birth control Brain Ischemia - etiology Case control studies Cohort Studies Contraceptives, Oral - adverse effects Cross-Sectional Studies Diabetes Disease risk General aspects Humans Hypertension Medical sciences Medical treatment Middle Aged Migraine Migraine Disorders - complications Neurology Observational studies Oral contraceptives Predisposing factors Regression Analysis Risk Factors Stroke Strokes Vascular diseases and vascular malformations of the nervous system
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Summary:	Abstract Objective To explore the association between migraine and risk of ischaemic stroke. Design Systematic review and meta-analysis. Data sources Observational studies published between 1966 and June 2004 (identified through Medline and Embase) that examined the association between migraine and risk of ischaemic stroke. Results 14 studies (11 case-control studies and 3 cohort studies) were identified. These studies suggest that the risk of stroke is increased in people with migraine (relative risk 2.16, 95% confidence interval 1.89 to 2.48). This increase in risk was consistent in people who had migraine with aura (relative risk 2.27, 1.61 to 3.19) and migraine without aura (relative risk 1.83, 1.06 to 3.15), as well as in those taking oral contraceptives (relative risk 8.72, 5.05 to 15.05). Conclusions Data from observational studies suggest that migraine may be a risk factor in developing stroke. More studies are needed to explore the mechanism of this potential association. In addition, the risk of migraine among users of oral contraceptives must be further investigated.
ISSN:	0959-8138 0959-8146 1468-5833 1756-1833