Recurrence of depressive disorders after interferon-induced depression

Interferon alpha (IFN-α)-treated patients commonly develop depression during the therapy period. Although most IFN-α-induced depressive disorders achieve remission after IFN-α therapy, no studies have examined the long-term mood effects of IFN-α treatment. We conducted a 12-year population-based coh...

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Bibliographic Details
Published in:Translational psychiatry 2017-02, Vol.7 (2), p.e1026-e1026
Main Authors: Chiu, W-C, Su, Y-P, Su, K-P, Chen, P-C
Format: Article
Language:English
Subjects:
Antiviral Agents - adverse effects
Case-Control Studies
Cohort Studies
Depressive Disorder - chemically induced
Depressive Disorder - epidemiology
Depressive Disorder, Major - chemically induced
Depressive Disorder, Major - epidemiology
Female
Hepatitis C, Chronic - drug therapy
Humans
Incidence
Interferon-alpha - adverse effects
Male
Middle Aged
Original
Proportional Hazards Models
Recurrence
Taiwan - epidemiology
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Summary:Interferon alpha (IFN-α)-treated patients commonly develop depression during the therapy period. Although most IFN-α-induced depressive disorders achieve remission after IFN-α therapy, no studies have examined the long-term mood effects of IFN-α treatment. We conducted a 12-year population-based cohort study of hepatitis C virus (HCV)-infected patients who were older than 20 years and had received IFN-α therapy. The sample was obtained from the Taiwan National Health Insurance Research Database. The cohort included patients with and without IFN-α-induced depression, matched randomly by age, sex and depression history, at a ratio of 1:10. The follow-up started after the last administration of IFN-α and was designed to determine the incidence of recurrent depressive disorder after IFN-α therapy. A total of 156 subjects were identified as having IFN-α-induced depression and achieving full remission after IFN-α therapy. The overall incidence of recurrent depressive disorders among patients with and without IFN-α-induced depression was 56.8 (95% confidence interval (CI), 42.4-76.1) and 4.1 (95% CI, 2.9-5.8) cases, respectively, per 100 000 person-years, P
ISSN:2158-3188
2158-3188
DOI:10.1038/tp.2016.274