Physiological and pathological roles of the γ-secretase complex

Highlights • The subunit composition and structure of gamma-secretase. • How the enzyme complex is regulated and trafficked. • The role of gamma-secretase in neural stem cells. • The contribution of non-canonical gamma-secretase substrates to neural processes.

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Bibliographic Details
Published in:Brain research bulletin 2016-09, Vol.126 (Pt 2), p.199-206
Main Authors: Carroll, Courtney M, Li, Yue-Ming
Format: Article
Language:English
Subjects:
Alzheimer Disease - enzymology
Alzheimer Disease - therapy
Alzheimer's disease
Amyloid Precursor Protein Secretases - metabolism
Amyloid-beta
Animals
Gamma-secretase
Humans
Neural Stem Cells - enzymology
Neurology
Neurons - enzymology
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Description
Summary:Highlights • The subunit composition and structure of gamma-secretase. • How the enzyme complex is regulated and trafficked. • The role of gamma-secretase in neural stem cells. • The contribution of non-canonical gamma-secretase substrates to neural processes.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2016.04.019