Association of peripheral NK cell counts with Helios+IFN‐γ– Tregs in patients with good long‐term renal allograft function

Summary Little is known about a possible interaction of natural killer (NK) cells with regulatory T cells (Treg) in long‐term stable kidney transplant recipients. Absolute counts of lymphocyte and Treg subsets were studied in whole blood samples of 136 long‐term stable renal transplant recipients an...

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Bibliographic Details
Published in:Clinical and experimental immunology 2017-06, Vol.188 (3), p.467-479
Main Authors: Trojan, K., Zhu, L., Aly, M., Weimer, R., Bulut, N., Morath, C., Opelz, G., Daniel, V.
Format: Article
Language:English
Subjects:
CD8+ lymphocytes
CTLA‐4
glomerular filtration rate
good long‐term renal allograft function
Helios+IFN‐γ– Treg
Original
peripheral NK cells
serum creatinine
TGF‐β
Treg subsets
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Summary:Summary Little is known about a possible interaction of natural killer (NK) cells with regulatory T cells (Treg) in long‐term stable kidney transplant recipients. Absolute counts of lymphocyte and Treg subsets were studied in whole blood samples of 136 long‐term stable renal transplant recipients and 52 healthy controls using eight‐colour fluorescence flow cytometry. Patients were 1946 ± 2201 days (153–10 268 days) post‐transplant and showed a serum creatinine of 1·7 ± 0·7 mg/dl. Renal transplant recipients investigated > 1·5 years post‐transplant showed higher total NK cell counts than recipients studied
ISSN:0009-9104
1365-2249
DOI:10.1111/cei.12945