Cardioprotective Effects of Malvidin Against Isoproterenol-Induced Myocardial Infarction in Rats: A Mechanistic Study

BACKGROUND Malvidin (alvidin-3-glucoside) is a polyphenol that belongs to the class of natural anthocyanin, which is abundantly found in red wines, colored fruits, and the skin of red grapes. Therefore, the current investigation was intended to evaluate the effect of malvidin against myocardial infa...

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Bibliographic Details
Published in:Medical science monitor 2017-04, Vol.23, p.2007-2016
Main Authors: Wei, Hui, Li, Hui, Wan, Shu-Ping, Zeng, Qiu-Tang, Cheng, Long-Xian, Jiang, Li-Li, Peng, Yu-Dong
Format: Article
Language:English
Subjects:
Animal Study
Animals
Anthocyanins - pharmacology
Anthocyanins - therapeutic use
Antioxidants - pharmacology
Catalase - drug effects
Catalase - metabolism
Enzyme-Linked Immunosorbent Assay
Glutathione Peroxidase - drug effects
Glutathione Peroxidase - metabolism
Heart - drug effects
Isoproterenol - pharmacology
Lipid Peroxidation - drug effects
Male
Myocardial Infarction - drug therapy
Myocardial Infarction - metabolism
Myocardial Infarction - prevention & control
Myocardium - pathology
Phytotherapy
Plant Extracts - pharmacology
Rats
Rats, Wistar
Superoxide Dismutase - drug effects
Superoxide Dismutase - metabolism
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Summary:BACKGROUND Malvidin (alvidin-3-glucoside) is a polyphenol that belongs to the class of natural anthocyanin, which is abundantly found in red wines, colored fruits, and the skin of red grapes. Therefore, the current investigation was intended to evaluate the effect of malvidin against myocardial infarction induced by isoproterenol in the rats. MATERIAL AND METHODS The cardioprotective effects was assessed by determining the effect of malvidin on the activities of endogenous antioxidants - catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH) - and on the levels of lipid peroxidation and serum marker enzymes. The serum levels of IL-6 and TNF-α were also determined using an enzyme-linked immunosorbent assay (ELISA) kit. RESULTS The present study demonstrated a significant cardioprotective effect of malvidin by restoring the defensive activities of endogenous antioxidants - catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH) - and by reducing the levels of lipid peroxidation and serum marker enzymes lactate dehydrogenase (LD) and creatine kinase (CK). Malvidin significantly ameliorated the histopathological changes and impaired mitochondria in the cardiac necrosis stimulated with isoproterenol. Additionally, the results also demonstrated that nuclear translocation of Nrf-2 and subsequent HO-1 expression might be associated with nuclear factor kappa B (NF-κB) pathway activation. CONCLUSIONS Our findings suggest that malvidin exerts cardioprotective effects that might be due to possible strong antioxidant and anti-inflammatory activities. Therefore, this study provides the basis for the development of malvidin as a safe and effective treatment of myocardial infarction.
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.902196