Global brain asymmetry is increased in schizophrenia and related to avolition

Objective Schizophrenia may be the result of a failure of the normal lateralization process of the brain. However, whole‐brain asymmetry has not been assessed up to date. Here, we propose a novel measure of global brain asymmetry based on the Dice coefficient to quantify similarity between brain hem...

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Bibliographic Details
Published in:Acta psychiatrica Scandinavica 2017-05, Vol.135 (5), p.448-459
Main Authors: Núñez, C., Paipa, N., Senior, C., Coromina, M., Siddi, S., Ochoa, S., Brébion, G., Stephan‐Otto, C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anxiety - diagnostic imaging
Asymmetry
Female
Gray Matter - diagnostic imaging
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging - methods
Male
Middle Aged
neurodevelopment
neuroimaging
Neuroimaging - methods
Neuropsychology
Psychopathology
Schizophrenia
Schizophrenia - diagnostic imaging
Schizophrenic Psychology
White Matter - diagnostic imaging
Young Adult
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Summary:Objective Schizophrenia may be the result of a failure of the normal lateralization process of the brain. However, whole‐brain asymmetry has not been assessed up to date. Here, we propose a novel measure of global brain asymmetry based on the Dice coefficient to quantify similarity between brain hemispheres. Method Global gray and white matter asymmetry was calculated from high‐resolution T1 structural images acquired from 24 patients with schizophrenia and 26 healthy controls, age‐ and sex‐matched. Some of the analyses were replicated in a much larger sample (n = 759) obtained from open‐access online databases. Results Patients with schizophrenia had more global gray matter asymmetry than controls. Additionally, increased gray matter asymmetry was associated with avolition, whereas the inverse relationship was found for anxiety at a trend level. These analyses were replicated in a larger sample and confirmed previous results. Conclusion Our findings suggest that global gray matter asymmetry is related to the concept of developmental stability and is a useful indicator of perturbations during neurodevelopment.
ISSN:0001-690X
1600-0447
DOI:10.1111/acps.12723