Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease

Oxidized low-density lipoprotein receptor 1 (OLR1) and interleukin 17A (IL17A) have pro-inflammatory roles in the development of cardiovascular disorders. The present study evaluated the association of OLR1 and IL17A and their polymorphisms with the development of femoropopliteal (FP) artery disease...

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Published in:Experimental and therapeutic medicine 2017-03, Vol.13 (3), p.1160-1168
Main Authors: Arslan, Caner, Bayoglu, Burcu, Tel, Cigdem, Cengiz, Mujgan, Dirican, Ahmet, Besirli, Kazim
Format: Article
Language:English
Subjects:
Age
Atherosclerosis
Blood glucose
Cardiovascular disease
Cholesterol
Confidence intervals
Cytokines
Gene expression
Heart surgery
Hypertension
Interleukin-17
Lipids
Low density lipoprotein
Medical imaging
Medical screening
Pathogenesis
Patients
Standard deviation
Values
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Tel, Cigdem
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description Oxidized low-density lipoprotein receptor 1 (OLR1) and interleukin 17A (IL17A) have pro-inflammatory roles in the development of cardiovascular disorders. The present study evaluated the association of OLR1 and IL17A and their polymorphisms with the development of femoropopliteal (FP) artery disease. The mRNA expression of OLR1 and IL17A in peripheral blood mononuclear cells as well as the frequency of OLR1 rs11053646 and IL17A rs8193037 and rs3819025 polymorphisms were assessed by polymerase chain reaction in 70 patients with FP artery disease and 80 age-matched disease-free controls. Furthermore, the levels of plasma cytokines were assessed by multiplex immunoassay. OLR1 and IL17A mRNA expression was significantly higher in patients with FP artery disease compared with that in controls (P
doi_str_mv 10.3892/etm.2017.4081
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The present study evaluated the association of OLR1 and IL17A and their polymorphisms with the development of femoropopliteal (FP) artery disease. The mRNA expression of OLR1 and IL17A in peripheral blood mononuclear cells as well as the frequency of OLR1 rs11053646 and IL17A rs8193037 and rs3819025 polymorphisms were assessed by polymerase chain reaction in 70 patients with FP artery disease and 80 age-matched disease-free controls. Furthermore, the levels of plasma cytokines were assessed by multiplex immunoassay. OLR1 and IL17A mRNA expression was significantly higher in patients with FP artery disease compared with that in controls (P&lt;0.001). No significant difference was observed in the genotypic frequencies of OLR1 rs11053646 (P=0.87) or in IL17A rs8193037 and rs3819025 (P=0.80 and 0.92, respectively) polymorphisms between patients with FP artery disease and controls. Plasma IL4, -6, -10, -22, -31 and -33 as well as soluble cluster of differentiation 40 ligand and tumor necrosis factor-α levels were significantly increased among FP artery disease patients compared with controls (P&lt;0.05). Furthermore, OLR1 expression was positively correlated with triglyceride (r=0.463, P&lt;0.001), low-density lipoprotein cholesterol (r=0.507, P&lt;0.001) and total cholesterol levels (r=0.357, P=0.006) in patients with FP artery disease. To the best of our knowledge, the present study was the first to identify an association between OLR1 and IL17A genes and FP artery disease. 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Plasma IL4, -6, -10, -22, -31 and -33 as well as soluble cluster of differentiation 40 ligand and tumor necrosis factor-α levels were significantly increased among FP artery disease patients compared with controls (P&lt;0.05). Furthermore, OLR1 expression was positively correlated with triglyceride (r=0.463, P&lt;0.001), low-density lipoprotein cholesterol (r=0.507, P&lt;0.001) and total cholesterol levels (r=0.357, P=0.006) in patients with FP artery disease. To the best of our knowledge, the present study was the first to identify an association between OLR1 and IL17A genes and FP artery disease. OLR1 and IL17A mRNA transcripts may be associated with blood lipid parameters and with the development of FP artery disease.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>28450958</pmid><doi>10.3892/etm.2017.4081</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5403327
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subjects Age
Atherosclerosis
Blood glucose
Cardiovascular disease
Cholesterol
Confidence intervals
Cytokines
Gene expression
Heart surgery
Hypertension
Interleukin-17
Lipids
Low density lipoprotein
Medical imaging
Medical screening
Pathogenesis
Patients
Standard deviation
Values
title Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease
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