Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease

Oxidized low-density lipoprotein receptor 1 (OLR1) and interleukin 17A (IL17A) have pro-inflammatory roles in the development of cardiovascular disorders. The present study evaluated the association of OLR1 and IL17A and their polymorphisms with the development of femoropopliteal (FP) artery disease...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2017-03, Vol.13 (3), p.1160-1168
Main Authors: Arslan, Caner, Bayoglu, Burcu, Tel, Cigdem, Cengiz, Mujgan, Dirican, Ahmet, Besirli, Kazim
Format: Article
Language:English
Subjects:
Age
Atherosclerosis
Blood glucose
Cardiovascular disease
Cholesterol
Confidence intervals
Cytokines
Gene expression
Heart surgery
Hypertension
Interleukin-17
Lipids
Low density lipoprotein
Medical imaging
Medical screening
Pathogenesis
Patients
Standard deviation
Values
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Summary:Oxidized low-density lipoprotein receptor 1 (OLR1) and interleukin 17A (IL17A) have pro-inflammatory roles in the development of cardiovascular disorders. The present study evaluated the association of OLR1 and IL17A and their polymorphisms with the development of femoropopliteal (FP) artery disease. The mRNA expression of OLR1 and IL17A in peripheral blood mononuclear cells as well as the frequency of OLR1 rs11053646 and IL17A rs8193037 and rs3819025 polymorphisms were assessed by polymerase chain reaction in 70 patients with FP artery disease and 80 age-matched disease-free controls. Furthermore, the levels of plasma cytokines were assessed by multiplex immunoassay. OLR1 and IL17A mRNA expression was significantly higher in patients with FP artery disease compared with that in controls (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2017.4081