Epigenetic silencing of protocadherin 10 in colorectal cancer

Epigenetic silencing of protocadherin 10 in colorectal cancer

Colorectal cancer (CRC) is one of the most common types of malignant tumor in the world and occurs through a multi-step process resulting from the accumulation of genetic and epigenetic alterations of the genome. Although the molecular mechanisms of the pathogenesis of CRC remain unclear, the inacti...

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Bibliographic Details
Published in:Oncology letters 2017-04, Vol.13 (4), p.2449-2453
Main Authors: Zhong, Xian, Shen, Hong, Mao, Jianshan, Zhang, Jiawei, Han, Weidong
Format: Article
Language:eng
Subjects:
Amino acids
Apoptosis
Biomarkers
Cell adhesion & migration
Cell cycle
Cell growth
Colorectal cancer
Deoxyribonucleic acid
DNA
DNA methylation
Drug resistance
Epigenetics
Gene expression
Kinases
Metastasis
Proteins
Review
Signal transduction
Studies
Tumorigenesis
Tumors
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Summary:Colorectal cancer (CRC) is one of the most common types of malignant tumor in the world and occurs through a multi-step process resulting from the accumulation of genetic and epigenetic alterations of the genome. Although the molecular mechanisms of the pathogenesis of CRC remain unclear, the inactivation of tumor suppressor genes (TSGs) through promoter methylation serves an important role. Aberrant methylation is a well-defined marker of CRC. At present, the epigenetic silencing of protocadherin 10 (PCDH10) has been identified as an important TSG with key roles in colorectal carcinogenesis, invasion and metastasis as a frequent and early event. Advances in gene methylation detection in tumor tissues and body fluids have led to the development of non-invasive screening methods for CRC. The present study aimed to review the epigenetic alteration of PCDH10 in CRC development, and the potential of PCDH10 to be a non-invasive biomarker for CRC.
ISSN:1792-1074
1792-1082