Comparative study of wound healing in rat skin following incision with a novel picosecond infrared laser (PIRL) and different surgical modalities

Background and Objective As a result of wound healing the original tissue is replaced by dysfunctional scar tissue. Reduced tissue damage during surgical procedures beneficially affects the size of the resulting scar and overall healing time. Thus the choice of a particular surgical instrument can h...

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Bibliographic Details
Published in:Lasers in surgery and medicine 2016-04, Vol.48 (4), p.385-391
Main Authors: Petersen, Hannes, Tavakoli, Fatemeh, Kruber, Sebastian, Münscher, Adrian, Gliese, Alexandra, Hansen, Nils-Owe, Uschold, Stephanie, Eggert, Dennis, Robertson, Wesley D., Gosau, Tobias, Sehner, Susanne, Kwiatkowski, Marcel, Schlüter, Hartmut, Schumacher, Udo, Knecht, Rainald, Miller, R.J. Dwayne
Format: Article
Language:English
Subjects:
animal model
Animals
Cicatrix - etiology
Cicatrix - prevention & control
Dermatologic Surgical Procedures - instrumentation
electrosurgery
Electrosurgery - instrumentation
electrosurgical device
Female
histology
Infrared Rays - therapeutic use
laser surgery
Laser Therapy - instrumentation
Lasers
Postoperative Complications - prevention & control
Pre‐Clinical Report
Pre‐Clinical Reports
Rats
scalpel
Treatment Outcome
Wound Healing
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Summary:Background and Objective As a result of wound healing the original tissue is replaced by dysfunctional scar tissue. Reduced tissue damage during surgical procedures beneficially affects the size of the resulting scar and overall healing time. Thus the choice of a particular surgical instrument can have a significant influence on the postoperative wound healing. To overcome these problems of wound healing we applied a novel picosecond infrared laser (PIRL) system to surgical incisions. Previous studies indicated that negligible thermal, acoustic, or ionization stress effects to the surrounding tissue results in a superior wound healing. Study Design/Materials and Methods Using the PIRL system as a surgical scalpel, we performed a prospective wound healing study on rat skin and assessed its final impact on scar formation compared to the electrosurgical device and cold steel. As for the incisions, 6 full‐thickness, 1‐cm long‐linear skin wounds were created on the dorsum of four rats using the PIRL, an electrosurgical device, and a conventional surgical scalpel, respectively. Rats were euthanized after 21 days of wound healing. The thickness of the subepithelial fibrosis, the depth and the transverse section of the total scar area of each wound were analyzed histologically. Results After 21 days of wound healing the incisions made by PIRL showed minor scar tissue formation as compared to the electrosurgical device and the scalpel. Highly significant differences (P 
ISSN:0196-8092
1096-9101
DOI:10.1002/lsm.22498