Cycle-Triggered Cortical Stimulation during Slow Wave Sleep Facilitates Learning a BMI Task: A Case Report in a Non-Human Primate

Slow wave sleep (SWS) has been identified as the sleep stage involved in consolidating newly acquired information. A growing body of evidence has shown that delta (1-4 Hz) oscillatory activity, the characteristic electroencephalographic signature of SWS, is involved in coordinating interaction betwe...

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Bibliographic Details
Published in:Frontiers in behavioral neuroscience 2017-04, Vol.11, p.59-59
Main Authors: Rembado, Irene, Zanos, Stavros, Fetz, Eberhard E
Format: Article
Language:English
Subjects:
Body mass index
Case reports
EEG
Electrical stimuli
Electrodes
Experiments
Homeostasis
Hypotheses
Information processing
Laboratory animals
Learning
Mental task performance
Neocortex
Neurons
Neuroscience
Oscillations
Prosthetics
Skills
Sleep
Synaptic plasticity
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Summary:Slow wave sleep (SWS) has been identified as the sleep stage involved in consolidating newly acquired information. A growing body of evidence has shown that delta (1-4 Hz) oscillatory activity, the characteristic electroencephalographic signature of SWS, is involved in coordinating interaction between the hippocampus and the neocortex and is thought to take a role in stabilizing memory traces related to a novel task. This case report describes a new protocol that uses neuroprosthetics training of a non-human primate to evaluate the effects of surface cortical electrical stimulation triggered from SWS cycles. The results suggest that stimulation phase-locked to SWS oscillatory activity promoted learning of the neuroprosthetic task. This protocol could be used to elucidate mechanisms of synaptic plasticity underlying off-line learning during sleep and offers new insights into the role of brain oscillations in information processing and memory consolidation.
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2017.00059