Subthalamic Nucleus Deep Brain Stimulation Alters Prefrontal Correlates of Emotion Induction

Objectives Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms in advanced Parkinson's disease. STN DBS may also affect emotion, possibly by impacting a parallel limbic cortico‐striatal circuit. The objective of this study was to investigate changes in prefront...

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Published in:Neuromodulation (Malden, Mass.) Mass.), 2017-04, Vol.20 (3), p.233-237
Main Authors: Bick, Sarah K. B., Folley, Bradley S., Mayer, Jutta S., Park, Sohee, Charles, P. David, Camalier, Corrie R., Pallavaram, Srivatsan, Konrad, Peter E., Neimat, Joseph S.
Format: Article
Language:English
Subjects:
Aged
Deep brain stimulation
Deep Brain Stimulation - methods
emotion
Female
Functional Laterality
Humans
Male
Middle Aged
Mood Disorders - etiology
Mood Disorders - therapy
near infrared spectroscopy
Neuropsychological Tests
Oxyhemoglobins - metabolism
Parkinson Disease - complications
Parkinson Disease - drug therapy
Parkinson's disease
Prefrontal Cortex - metabolism
Prefrontal Cortex - physiopathology
Spectroscopy, Near-Infrared
subthalamic nucleus
Subthalamic Nucleus - physiology
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Summary:Objectives Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms in advanced Parkinson's disease. STN DBS may also affect emotion, possibly by impacting a parallel limbic cortico‐striatal circuit. The objective of this study was to investigate changes in prefrontal cortical activity related to DBS during an emotion induction task. Materials and Methods We used near infrared spectroscopy to monitor prefrontal cortex hemodynamic changes during an emotion induction task. Seven DBS patients were tested sequentially in the stimulation‐on and stimulation‐off states while on dopaminergic medication. Patients watched a series of positive, negative, and neutral videos. The general linear model was used to compare prefrontal oxygenated hemoglobin concentration between DBS states. Results Deep brain stimulation was correlated with prefrontal oxygenated hemoglobin changes relative to the stimulation off state in response to both positive and negative videos. These changes were specific to emotional stimuli and were not seen during neutral stimuli. Conclusions These results suggest that STN stimulation influences the prefrontal cortical representation of positive and negative emotion induction.
ISSN:1094-7159
1525-1403
DOI:10.1111/ner.12537