Placental ABC Transporters: Biological Impact and Pharmaceutical Significance

The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abu...

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Bibliographic Details
Published in:Pharmaceutical Research 2016-12, Vol.33 (12), p.2847-2878
Main Authors: Joshi, Anand A., Vaidya, Soniya S., St-Pierre, Marie V., Mikheev, Andrei M., Desino, Kelly E., Nyandege, Abner N., Audus, Kenneth L., Unadkat, Jashvant D., Gerk, Phillip M.
Format: Article
Language:English
Subjects:
Biochemistry
Biology
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Expert Review
Health aspects
Medical Law
Pharmaceuticals
Pharmacology/Toxicology
Pharmacy
Placenta
Pregnant women
Prenatal care
Xenobiotics
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Summary:The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abuse, and other xenobiotics. To date, considerable progress has been made toward understanding ABC transporters in the placenta. Recent studies on the expression and functional activities are discussed. This review discusses the placental expression and functional roles of several members of ABC transporter subfamilies B, C, and G including MDR1/P-glycoprotein, the MRPs, and BCRP, respectively. Since placental ABC transporters modulate fetal exposure to various compounds, an understanding of their functional and regulatory mechanisms will lead to more optimal medication use when necessary in pregnancy.
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-016-2028-8