Abundant collateralization of temporal lobe projections to the accumbens, bed nucleus of stria terminalis, central amygdala and lateral septum

Behavioral flexibility is subserved in part by outputs from the cerebral cortex to telencephalic subcortical structures. In our earlier evaluation of the organization of the cortical–subcortical output system (Reynolds and Zahm, J Neurosci 25:11757–11767, 2005 ), retrograde double-labeling was evalu...

Full description

Saved in:
Bibliographic Details
Published in:Brain Structure and Function 2017-05, Vol.222 (4), p.1971-1988
Main Authors: Reichard, Rhett A., Subramanian, Suriya, Desta, Mikiyas T., Sura, Tej, Becker, Mary L., Ghobadi, Comeron W., Parsley, Kenneth P., Zahm, Daniel S.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Central Amygdaloid Nucleus - cytology
Male
Neural Pathways - cytology
Neuroanatomical Tract-Tracing Techniques
Neurology
Neurons - cytology
Neurosciences
Nucleus Accumbens - cytology
Original Article
Rats, Sprague-Dawley
Septal Nuclei - cytology
Temporal Lobe - cytology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Behavioral flexibility is subserved in part by outputs from the cerebral cortex to telencephalic subcortical structures. In our earlier evaluation of the organization of the cortical–subcortical output system (Reynolds and Zahm, J Neurosci 25:11757–11767, 2005 ), retrograde double-labeling was evaluated in the prefrontal cortex following tracer injections into pairs of the following subcortical telencephalic structures: caudate–putamen, core and shell of the accumbens (Acb), bed nucleus of stria terminalis (BST) and central nucleus of the amygdala (CeA). The present study was done to assess patterns of retrograde labeling in the temporal lobe after similar paired tracer injections into most of the same telencephalic structures plus the lateral septum (LS). In contrast to the modest double-labeling observed in the prefrontal cortex in the previous study, up to 60–80 % of neurons in the basal and accessory basal amygdaloid nuclei and amygdalopiriform transition area exhibited double-labeling in the present study. The most abundant double-labeling was generated by paired injections into structures affiliated with the extended amygdala, including the CeA, BST and Acb shell. Injections pairing the Acb core with the BST or CeA produced significantly fewer double-labeled neurons. The ventral subiculum exhibited modest amounts of double-labeling associated with paired injections into the Acb, BST, CeA and LS. The results raise the issue of how an extraordinarily collateralized output from the temporal lobe may contribute to behavioral flexibility.
ISSN:1863-2653
1863-2661
0340-2061
DOI:10.1007/s00429-016-1321-y