MET4 expression predicts poor prognosis of gastric cancers with Helicobacter pylori infection

The role of HGF/SF‐MET signaling is important in cancer progression, but its relation with Helicobacter pylori‐positive gastric cancers remains to be elucidated. In total, 201 patients with primary gastric carcinoma who underwent curative or debulking resection without preoperative chemotherapy were...

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Bibliographic Details
Published in:	Cancer science 2017-03, Vol.108 (3), p.322-330
Main Authors:	Sakamoto, Naoko, Tsujimoto, Hironori, Takahata, Risa, Cao, Brian, Zhao, Ping, Ito, Nozomi, Shimazaki, Hideyuki, Ichikura, Takashi, Hase, Kazuo, Vande Woude, George F., Shinomiya, Nariyoshi
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Biomarkers, Tumor Female Gastric cancer Gastric Mucosa - pathology Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori Hepatocyte Growth Factor - metabolism Humans Kaplan-Meier Estimate Male MET MET4 antibody Middle Aged Original Prognosis Proportional Hazards Models Proto-Oncogene Proteins c-met - metabolism Stomach Neoplasms - microbiology Stomach Neoplasms - pathology
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Summary:	The role of HGF/SF‐MET signaling is important in cancer progression, but its relation with Helicobacter pylori‐positive gastric cancers remains to be elucidated. In total, 201 patients with primary gastric carcinoma who underwent curative or debulking resection without preoperative chemotherapy were studied. MET4 and anti‐HGF/SF mAbs were used for immunohistochemical analysis. Survival of gastric cancer patients was estimated by Kaplan–Meier method and compared with log‐rank. Cox proportional hazards models were fit to determine the independent association of MET‐staining status with outcome. The effect of live H. pylori bacteria on cell signaling and biological behaviors was evaluated using gastric cancer cell lines. MET4‐positive gastric cancers showed poorer prognosis than MET4‐negative cases (overall survival, P = 0.02; relapse‐free survival, P = 0.06). Positive staining for MET4 was also a statistically significant factor to predict poor prognosis in H. pylori‐positive cases (overall survival, P
ISSN:	1347-9032 1349-7006