Possible functions of CD169‐positive sinus macrophages in lymph nodes in anti‐tumor immune responses

The lymph node (LN) is an important immune system in which a number of antigen‐presenting cells are present that induce rapid immune responses to foreign antigens. While a great number of macrophages exist in lymph nodes, recent studies using animal models have shown that lymph node sinus macrophage...

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Bibliographic Details
Published in:Cancer science 2017-03, Vol.108 (3), p.290-295
Main Authors: Komohara, Yoshihiro, Ohnishi, Koji, Takeya, Motohiro
Format: Article
Language:English
Subjects:
Cancer immunology
CD169
Colorectal Neoplasms - immunology
Endometrial Neoplasms - immunology
Female
Humans
Killer Cells, Natural - immunology
lymph node
Lymph Nodes - pathology
Macrophages - immunology
Melanoma - immunology
Review
Sialic Acid Binding Ig-like Lectin 1 - metabolism
sinus macrophage
T-Lymphocytes - immunology
tumor‐associated macrophage
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Summary:The lymph node (LN) is an important immune system in which a number of antigen‐presenting cells are present that induce rapid immune responses to foreign antigens. While a great number of macrophages exist in lymph nodes, recent studies using animal models have shown that lymph node sinus macrophages are associated with the induction of anti‐tumor immunity, playing a significant role in host immune responses against tumor cells. In colorectal tumor, malignant melanoma, and endometrial tumor, it was shown that a high density of CD169‐positive macrophages in the LN sinus was a predictive factor for better clinical prognosis. The observations that the density of CD169‐positive macrophages in the LN sinus was positively associated with the density of infiltrating T or NK cells in tumor tissues, indicates the significance of CD169‐positive macrophages in anti‐tumor immune reactions of tumor patients. Moreover, antigen delivery targeting LN macrophages is also considered to be promising approach for vaccination. In this article, we have summarized the significance of CD169‐positive LN macrophages in anti‐tumor immunity. The lymph node (LN) is an important immune system in which a number of antigen‐presenting cells (APCs) are present that induce rapid immune responses to foreign antigens. The observations that the density of CD169‐positive macrophages in the LN sinus was positively associated with the density of infiltrating T or NK cells in tumor tissues, indicates the significance of CD169‐positive macrophages in anti‐tumor immune reactions of tumor patients. In this article, we have summarized the significance of CD169‐positive LN macrophages in anti‐tumor immunity.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.13137