Electrochemical Biosensors for Early Stage Zika Diagnostics

Health agencies have declared the recent Zika virus (ZIKV) infection an epidemic and a public health emergency of global concern due to its association with microcephaly and serious neurological disorders. The unavailability of effective drugs, vaccines, and diagnostic tools increases the demand for...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2017-04, Vol.35 (4), p.308-317
Main Authors: Kaushik, Ajeet, Tiwari, Sneham, Jayant, Rahul D, Vashist, Arti, Nikkhah-Moshaie, Roozbeh, El-Hage, Nazira, Nair, Madhavan
Format: Article
Language:English
Subjects:
Aedes - virology
Animals
Biosensing Techniques
Biosensors
Chromium
Cost analysis
Detection
Devices
Diagnostic software
Diagnostic systems
Early Diagnosis
electrochemical biosensor
Electrochemical Techniques
Electrochemistry
Emergencies
Epidemics
Epidemiology
Flavivirus
HIV
Hormones
Human immunodeficiency virus
Humans
Infections
Infectious diseases
Internal Medicine
Microencephaly
Microfluidic Analytical Techniques
Monitors
Mosquitoes
Nanotechnology
Neurological diseases
Pathogenesis
Pathogens
point-of-care sensing systems
Public health
Reverse Transcriptase Polymerase Chain Reaction
RNA-directed DNA polymerase
System effectiveness
Trends
Urine
Vaccines
Vector-borne diseases
Viral infections
Viruses
Zika virus
Zika Virus - genetics
Zika Virus - isolation & purification
Zika virus infection
Zika Virus Infection - diagnosis
Zika Virus Infection - transmission
Zika Virus Infection - virology
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Summary:Health agencies have declared the recent Zika virus (ZIKV) infection an epidemic and a public health emergency of global concern due to its association with microcephaly and serious neurological disorders. The unavailability of effective drugs, vaccines, and diagnostic tools increases the demand for efficient analytical devices to detect ZIKV infection. However, high costs, longer diagnostic times, and stringent expertise requirements limit the utility of reverse transcriptase-PCR methods for rapid diagnostics. Therefore, developing portable, sensitive, selective, and cost-effective sensing systems to detect ZIKV at picomolar concentrations in biofluids would be a breakthrough in diagnostics and therapeutics. This paper highlights the advancements in developing smart sensing strategies to monitor ZIKV progression, with rapid point-of-care diagnostics as the ultimate aim.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2016.10.001