Evaluation of biomarker canine-prostate specific arginine esterase (CPSE) for the diagnosis of benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH) is the most common canine prostatic disorder. Although most or even all intact male dogs may develop BPH by 5-8 years of age, many show no clinical signs. Taking into account the non-specific character of clinical and ultrasonographic findings, a new diagnostic app...

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Bibliographic Details
Published in:BMC veterinary research 2017-03, Vol.13 (1), p.76-76, Article 76
Main Authors: Pinheiro, Dora, Machado, João, Viegas, Carlos, Baptista, Cláudia, Bastos, Estela, Magalhães, Joana, Pires, Maria A, Cardoso, Luís, Martins-Bessa, Ana
Format: Article
Language:English
Subjects:
Androgens
Animals
Arginine
Benign
Biomarkers - blood
Carboxylic Ester Hydrolases - blood
Case-Control Studies
Cellular biology
Constipation
Cysts
Cytoplasm
Disease
Dog Diseases - blood
Dog Diseases - diagnosis
Dogs
Esterase
Hyperplasia
Infertility
Inflammatory diseases
Male
Middle age
Morphology
Neutrophils
Pain
Plasma
Prostate
Prostate - pathology
Prostate cancer
Prostatic Hyperplasia - blood
Prostatic Hyperplasia - diagnosis
Prostatic Hyperplasia - veterinary
Sensitivity and Specificity
Test procedures
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Summary:Benign prostatic hyperplasia (BPH) is the most common canine prostatic disorder. Although most or even all intact male dogs may develop BPH by 5-8 years of age, many show no clinical signs. Taking into account the non-specific character of clinical and ultrasonographic findings, a new diagnostic approach has recently been proposed based on the augmentation of blood canine prostate-specific arginine esterase (CPSE) in hyperplasic dogs. The aim of the present study was to verify CPSE levels in negative controls and hyperplasic dogs, considering cytological findings as the reference method and taking into account the fact that controls were middle-aged intact dogs (median of 5.0 years), contrarily to previous studies carried out with very young control dogs. Significant differences of median CPSE levels were found between controls and hyperplasic dogs (29.1 versus 160.7 ng/mL, respectively); and significant positive correlations were found between median CPSE levels and age or prostatic volume (r = 0.549 and 0.448, respectively; p 
ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-017-0996-5