Real-time in vivo monitoring of magnetic nanoparticles in the bloodstream by AC biosusceptometry

We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versatile, non-invasive, and accessible tool to study pharmacokinetic parameters of MNPs, such a...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nanobiotechnology 2017-03, Vol.15 (1), p.22, Article 22
Main Authors: Próspero, André G, Quini, Caio C, Bakuzis, Andris F, Fidelis-de-Oliveira, Patrícia, Moretto, Gustavo M, Mello, Fábio P F, Calabresi, Marcos F F, Matos, Ronaldo V R, Zandoná, Ednaldo A, Zufelato, Nícholas, Oliveira, Ricardo B, Miranda, José R A
Format: Article
Language:English
Subjects:
Animals
Arrhythmia
Arrhythmias, Cardiac - chemically induced
Blood Circulation Time
Blood Pressure
EKG
Electrocardiography
Ferric Compounds - blood
Ferric Compounds - pharmacokinetics
Heart Rate
In vivo methods and tests
Injection
Iron
Iron oxides
Magnetics
Magnetite Nanoparticles - chemistry
Magnetometry - methods
Male
Manganese
Methods
Nanoparticles
NMR
Nuclear magnetic resonance
Particle Size
Physiology
Pressure drop
Rats
Rats, Wistar
Rodents
Studies
Therapeutic applications
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c394t-eb3b78a30c89a61befd8953c7436a883dd10799668a5b4d0b3a0b75e24aacbac3
cites cdi_FETCH-LOGICAL-c394t-eb3b78a30c89a61befd8953c7436a883dd10799668a5b4d0b3a0b75e24aacbac3
container_end_page
container_issue 1
container_start_page 22
container_title Journal of nanobiotechnology
container_volume 15
creator Próspero, André G
Quini, Caio C
Bakuzis, Andris F
Fidelis-de-Oliveira, Patrícia
Moretto, Gustavo M
Mello, Fábio P F
Calabresi, Marcos F F
Matos, Ronaldo V R
Zandoná, Ednaldo A
Zufelato, Nícholas
Oliveira, Ricardo B
Miranda, José R A
description We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versatile, non-invasive, and accessible tool to study pharmacokinetic parameters of MNPs, such as circulation time, in real time. We synthesized and monitored manganese doped iron oxide nanoparticles in the bloodstream of Wistar rats using two different injection protocols. Aiming towards a translational approach, we also simultaneously evaluated cardiovascular parameters, including mean arterial pressure, heart rate, and episodes of arrhythmia in order to secure the well-being of all animals. We found that serial injections increased the circulation time compared with single injections. Immediately after each injection, we observed a transitory drop in arterial pressure, a small drop in heart rate, and no episodes of arrhythmia. Although some cardiovascular effects were observed, they were transitory and easily recovered in both protocols. These results indicate that the ACB system may be a valuable tool for in vivo, real-time MNP monitoring that allows associations with other techniques, such as pulsatile arterial pressure and electrocardiogram recordings, helping ensuring the protocol safety, which is a fundamental step towards clinical applications.
doi_str_mv 10.1186/s12951-017-0257-6
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5361818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1884195344</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-eb3b78a30c89a61befd8953c7436a883dd10799668a5b4d0b3a0b75e24aacbac3</originalsourceid><addsrcrecordid>eNpVkU9rGzEQxUVJqBO3H6CXIsh5E81Ku9JeCsGkf8AQCMlZHWllW2FXciXZ4G_fNXZDepqBee_Ngx8hX4DdAqj2LkPdNVAxkBWrG1m1H8gVCCkrDk1z8W6fkeucXxmra1GLj2RWK15L6OCK_H5yOFTFj476QPd-H-kYgy8x-bCmcUVHXAdXvKUBQ9ximtbB5aO4bBw1Q4x9LsnhSM2B3i-o8THvsnXbEkdX0uETuVzhkN3n85yTl-8Pz4uf1fLxx6_F_bKyvBOlcoYbqZAzqzpswbhVr7qGWyl4i0rxvgcmu65tFTZG9MxwZEY2rhaI1qDlc_LtlLvdmdH11oWScNDb5EdMBx3R6_8vwW_0Ou51w1tQoKaAm3NAin92Lhf9GncpTJ01KCVgaiPEpIKTyqaYc3Krtw_A9BGKPkHRExR9hKLbyfP1fbU3xz8K_C_Z6op3</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1884195344</pqid></control><display><type>article</type><title>Real-time in vivo monitoring of magnetic nanoparticles in the bloodstream by AC biosusceptometry</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Próspero, André G ; Quini, Caio C ; Bakuzis, Andris F ; Fidelis-de-Oliveira, Patrícia ; Moretto, Gustavo M ; Mello, Fábio P F ; Calabresi, Marcos F F ; Matos, Ronaldo V R ; Zandoná, Ednaldo A ; Zufelato, Nícholas ; Oliveira, Ricardo B ; Miranda, José R A</creator><creatorcontrib>Próspero, André G ; Quini, Caio C ; Bakuzis, Andris F ; Fidelis-de-Oliveira, Patrícia ; Moretto, Gustavo M ; Mello, Fábio P F ; Calabresi, Marcos F F ; Matos, Ronaldo V R ; Zandoná, Ednaldo A ; Zufelato, Nícholas ; Oliveira, Ricardo B ; Miranda, José R A</creatorcontrib><description>We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versatile, non-invasive, and accessible tool to study pharmacokinetic parameters of MNPs, such as circulation time, in real time. We synthesized and monitored manganese doped iron oxide nanoparticles in the bloodstream of Wistar rats using two different injection protocols. Aiming towards a translational approach, we also simultaneously evaluated cardiovascular parameters, including mean arterial pressure, heart rate, and episodes of arrhythmia in order to secure the well-being of all animals. We found that serial injections increased the circulation time compared with single injections. Immediately after each injection, we observed a transitory drop in arterial pressure, a small drop in heart rate, and no episodes of arrhythmia. Although some cardiovascular effects were observed, they were transitory and easily recovered in both protocols. These results indicate that the ACB system may be a valuable tool for in vivo, real-time MNP monitoring that allows associations with other techniques, such as pulsatile arterial pressure and electrocardiogram recordings, helping ensuring the protocol safety, which is a fundamental step towards clinical applications.</description><identifier>ISSN: 1477-3155</identifier><identifier>EISSN: 1477-3155</identifier><identifier>DOI: 10.1186/s12951-017-0257-6</identifier><identifier>PMID: 28327191</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Animals ; Arrhythmia ; Arrhythmias, Cardiac - chemically induced ; Blood Circulation Time ; Blood Pressure ; EKG ; Electrocardiography ; Ferric Compounds - blood ; Ferric Compounds - pharmacokinetics ; Heart Rate ; In vivo methods and tests ; Injection ; Iron ; Iron oxides ; Magnetics ; Magnetite Nanoparticles - chemistry ; Magnetometry - methods ; Male ; Manganese ; Methods ; Nanoparticles ; NMR ; Nuclear magnetic resonance ; Particle Size ; Physiology ; Pressure drop ; Rats ; Rats, Wistar ; Rodents ; Studies ; Therapeutic applications</subject><ispartof>Journal of nanobiotechnology, 2017-03, Vol.15 (1), p.22, Article 22</ispartof><rights>Copyright BioMed Central 2017</rights><rights>The Author(s) 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-eb3b78a30c89a61befd8953c7436a883dd10799668a5b4d0b3a0b75e24aacbac3</citedby><cites>FETCH-LOGICAL-c394t-eb3b78a30c89a61befd8953c7436a883dd10799668a5b4d0b3a0b75e24aacbac3</cites><orcidid>0000-0003-3366-106X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361818/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1884195344?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,44625,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28327191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Próspero, André G</creatorcontrib><creatorcontrib>Quini, Caio C</creatorcontrib><creatorcontrib>Bakuzis, Andris F</creatorcontrib><creatorcontrib>Fidelis-de-Oliveira, Patrícia</creatorcontrib><creatorcontrib>Moretto, Gustavo M</creatorcontrib><creatorcontrib>Mello, Fábio P F</creatorcontrib><creatorcontrib>Calabresi, Marcos F F</creatorcontrib><creatorcontrib>Matos, Ronaldo V R</creatorcontrib><creatorcontrib>Zandoná, Ednaldo A</creatorcontrib><creatorcontrib>Zufelato, Nícholas</creatorcontrib><creatorcontrib>Oliveira, Ricardo B</creatorcontrib><creatorcontrib>Miranda, José R A</creatorcontrib><title>Real-time in vivo monitoring of magnetic nanoparticles in the bloodstream by AC biosusceptometry</title><title>Journal of nanobiotechnology</title><addtitle>J Nanobiotechnology</addtitle><description>We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versatile, non-invasive, and accessible tool to study pharmacokinetic parameters of MNPs, such as circulation time, in real time. We synthesized and monitored manganese doped iron oxide nanoparticles in the bloodstream of Wistar rats using two different injection protocols. Aiming towards a translational approach, we also simultaneously evaluated cardiovascular parameters, including mean arterial pressure, heart rate, and episodes of arrhythmia in order to secure the well-being of all animals. We found that serial injections increased the circulation time compared with single injections. Immediately after each injection, we observed a transitory drop in arterial pressure, a small drop in heart rate, and no episodes of arrhythmia. Although some cardiovascular effects were observed, they were transitory and easily recovered in both protocols. These results indicate that the ACB system may be a valuable tool for in vivo, real-time MNP monitoring that allows associations with other techniques, such as pulsatile arterial pressure and electrocardiogram recordings, helping ensuring the protocol safety, which is a fundamental step towards clinical applications.</description><subject>Animals</subject><subject>Arrhythmia</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Blood Circulation Time</subject><subject>Blood Pressure</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Ferric Compounds - blood</subject><subject>Ferric Compounds - pharmacokinetics</subject><subject>Heart Rate</subject><subject>In vivo methods and tests</subject><subject>Injection</subject><subject>Iron</subject><subject>Iron oxides</subject><subject>Magnetics</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Magnetometry - methods</subject><subject>Male</subject><subject>Manganese</subject><subject>Methods</subject><subject>Nanoparticles</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Particle Size</subject><subject>Physiology</subject><subject>Pressure drop</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Studies</subject><subject>Therapeutic applications</subject><issn>1477-3155</issn><issn>1477-3155</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpVkU9rGzEQxUVJqBO3H6CXIsh5E81Ku9JeCsGkf8AQCMlZHWllW2FXciXZ4G_fNXZDepqBee_Ngx8hX4DdAqj2LkPdNVAxkBWrG1m1H8gVCCkrDk1z8W6fkeucXxmra1GLj2RWK15L6OCK_H5yOFTFj476QPd-H-kYgy8x-bCmcUVHXAdXvKUBQ9ximtbB5aO4bBw1Q4x9LsnhSM2B3i-o8THvsnXbEkdX0uETuVzhkN3n85yTl-8Pz4uf1fLxx6_F_bKyvBOlcoYbqZAzqzpswbhVr7qGWyl4i0rxvgcmu65tFTZG9MxwZEY2rhaI1qDlc_LtlLvdmdH11oWScNDb5EdMBx3R6_8vwW_0Ou51w1tQoKaAm3NAin92Lhf9GncpTJ01KCVgaiPEpIKTyqaYc3Krtw_A9BGKPkHRExR9hKLbyfP1fbU3xz8K_C_Z6op3</recordid><startdate>20170321</startdate><enddate>20170321</enddate><creator>Próspero, André G</creator><creator>Quini, Caio C</creator><creator>Bakuzis, Andris F</creator><creator>Fidelis-de-Oliveira, Patrícia</creator><creator>Moretto, Gustavo M</creator><creator>Mello, Fábio P F</creator><creator>Calabresi, Marcos F F</creator><creator>Matos, Ronaldo V R</creator><creator>Zandoná, Ednaldo A</creator><creator>Zufelato, Nícholas</creator><creator>Oliveira, Ricardo B</creator><creator>Miranda, José R A</creator><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7TB</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3366-106X</orcidid></search><sort><creationdate>20170321</creationdate><title>Real-time in vivo monitoring of magnetic nanoparticles in the bloodstream by AC biosusceptometry</title><author>Próspero, André G ; Quini, Caio C ; Bakuzis, Andris F ; Fidelis-de-Oliveira, Patrícia ; Moretto, Gustavo M ; Mello, Fábio P F ; Calabresi, Marcos F F ; Matos, Ronaldo V R ; Zandoná, Ednaldo A ; Zufelato, Nícholas ; Oliveira, Ricardo B ; Miranda, José R A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-eb3b78a30c89a61befd8953c7436a883dd10799668a5b4d0b3a0b75e24aacbac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Arrhythmia</topic><topic>Arrhythmias, Cardiac - chemically induced</topic><topic>Blood Circulation Time</topic><topic>Blood Pressure</topic><topic>EKG</topic><topic>Electrocardiography</topic><topic>Ferric Compounds - blood</topic><topic>Ferric Compounds - pharmacokinetics</topic><topic>Heart Rate</topic><topic>In vivo methods and tests</topic><topic>Injection</topic><topic>Iron</topic><topic>Iron oxides</topic><topic>Magnetics</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Magnetometry - methods</topic><topic>Male</topic><topic>Manganese</topic><topic>Methods</topic><topic>Nanoparticles</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Particle Size</topic><topic>Physiology</topic><topic>Pressure drop</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Studies</topic><topic>Therapeutic applications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Próspero, André G</creatorcontrib><creatorcontrib>Quini, Caio C</creatorcontrib><creatorcontrib>Bakuzis, Andris F</creatorcontrib><creatorcontrib>Fidelis-de-Oliveira, Patrícia</creatorcontrib><creatorcontrib>Moretto, Gustavo M</creatorcontrib><creatorcontrib>Mello, Fábio P F</creatorcontrib><creatorcontrib>Calabresi, Marcos F F</creatorcontrib><creatorcontrib>Matos, Ronaldo V R</creatorcontrib><creatorcontrib>Zandoná, Ednaldo A</creatorcontrib><creatorcontrib>Zufelato, Nícholas</creatorcontrib><creatorcontrib>Oliveira, Ricardo B</creatorcontrib><creatorcontrib>Miranda, José R A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of nanobiotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Próspero, André G</au><au>Quini, Caio C</au><au>Bakuzis, Andris F</au><au>Fidelis-de-Oliveira, Patrícia</au><au>Moretto, Gustavo M</au><au>Mello, Fábio P F</au><au>Calabresi, Marcos F F</au><au>Matos, Ronaldo V R</au><au>Zandoná, Ednaldo A</au><au>Zufelato, Nícholas</au><au>Oliveira, Ricardo B</au><au>Miranda, José R A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Real-time in vivo monitoring of magnetic nanoparticles in the bloodstream by AC biosusceptometry</atitle><jtitle>Journal of nanobiotechnology</jtitle><addtitle>J Nanobiotechnology</addtitle><date>2017-03-21</date><risdate>2017</risdate><volume>15</volume><issue>1</issue><spage>22</spage><pages>22-</pages><artnum>22</artnum><issn>1477-3155</issn><eissn>1477-3155</eissn><abstract>We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versatile, non-invasive, and accessible tool to study pharmacokinetic parameters of MNPs, such as circulation time, in real time. We synthesized and monitored manganese doped iron oxide nanoparticles in the bloodstream of Wistar rats using two different injection protocols. Aiming towards a translational approach, we also simultaneously evaluated cardiovascular parameters, including mean arterial pressure, heart rate, and episodes of arrhythmia in order to secure the well-being of all animals. We found that serial injections increased the circulation time compared with single injections. Immediately after each injection, we observed a transitory drop in arterial pressure, a small drop in heart rate, and no episodes of arrhythmia. Although some cardiovascular effects were observed, they were transitory and easily recovered in both protocols. These results indicate that the ACB system may be a valuable tool for in vivo, real-time MNP monitoring that allows associations with other techniques, such as pulsatile arterial pressure and electrocardiogram recordings, helping ensuring the protocol safety, which is a fundamental step towards clinical applications.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>28327191</pmid><doi>10.1186/s12951-017-0257-6</doi><orcidid>https://orcid.org/0000-0003-3366-106X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1477-3155
ispartof Journal of nanobiotechnology, 2017-03, Vol.15 (1), p.22, Article 22
issn 1477-3155
1477-3155
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5361818
source Publicly Available Content Database; PubMed Central
subjects Animals
Arrhythmia
Arrhythmias, Cardiac - chemically induced
Blood Circulation Time
Blood Pressure
EKG
Electrocardiography
Ferric Compounds - blood
Ferric Compounds - pharmacokinetics
Heart Rate
In vivo methods and tests
Injection
Iron
Iron oxides
Magnetics
Magnetite Nanoparticles - chemistry
Magnetometry - methods
Male
Manganese
Methods
Nanoparticles
NMR
Nuclear magnetic resonance
Particle Size
Physiology
Pressure drop
Rats
Rats, Wistar
Rodents
Studies
Therapeutic applications
title Real-time in vivo monitoring of magnetic nanoparticles in the bloodstream by AC biosusceptometry
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T17%3A08%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Real-time%20in%20vivo%20monitoring%20of%20magnetic%20nanoparticles%20in%20the%20bloodstream%20by%20AC%20biosusceptometry&rft.jtitle=Journal%20of%20nanobiotechnology&rft.au=Pr%C3%B3spero,%20Andr%C3%A9%20G&rft.date=2017-03-21&rft.volume=15&rft.issue=1&rft.spage=22&rft.pages=22-&rft.artnum=22&rft.issn=1477-3155&rft.eissn=1477-3155&rft_id=info:doi/10.1186/s12951-017-0257-6&rft_dat=%3Cproquest_pubme%3E1884195344%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c394t-eb3b78a30c89a61befd8953c7436a883dd10799668a5b4d0b3a0b75e24aacbac3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1884195344&rft_id=info:pmid/28327191&rfr_iscdi=true