Real-time in vivo monitoring of magnetic nanoparticles in the bloodstream by AC biosusceptometry

We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versatile, non-invasive, and accessible tool to study pharmacokinetic parameters of MNPs, such a...

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Bibliographic Details
Published in:Journal of nanobiotechnology 2017-03, Vol.15 (1), p.22, Article 22
Main Authors: Próspero, André G, Quini, Caio C, Bakuzis, Andris F, Fidelis-de-Oliveira, Patrícia, Moretto, Gustavo M, Mello, Fábio P F, Calabresi, Marcos F F, Matos, Ronaldo V R, Zandoná, Ednaldo A, Zufelato, Nícholas, Oliveira, Ricardo B, Miranda, José R A
Format: Article
Language:English
Subjects:
Animals
Arrhythmia
Arrhythmias, Cardiac - chemically induced
Blood Circulation Time
Blood Pressure
EKG
Electrocardiography
Ferric Compounds - blood
Ferric Compounds - pharmacokinetics
Heart Rate
In vivo methods and tests
Injection
Iron
Iron oxides
Magnetics
Magnetite Nanoparticles - chemistry
Magnetometry - methods
Male
Manganese
Methods
Nanoparticles
NMR
Nuclear magnetic resonance
Particle Size
Physiology
Pressure drop
Rats
Rats, Wistar
Rodents
Studies
Therapeutic applications
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Summary:We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versatile, non-invasive, and accessible tool to study pharmacokinetic parameters of MNPs, such as circulation time, in real time. We synthesized and monitored manganese doped iron oxide nanoparticles in the bloodstream of Wistar rats using two different injection protocols. Aiming towards a translational approach, we also simultaneously evaluated cardiovascular parameters, including mean arterial pressure, heart rate, and episodes of arrhythmia in order to secure the well-being of all animals. We found that serial injections increased the circulation time compared with single injections. Immediately after each injection, we observed a transitory drop in arterial pressure, a small drop in heart rate, and no episodes of arrhythmia. Although some cardiovascular effects were observed, they were transitory and easily recovered in both protocols. These results indicate that the ACB system may be a valuable tool for in vivo, real-time MNP monitoring that allows associations with other techniques, such as pulsatile arterial pressure and electrocardiogram recordings, helping ensuring the protocol safety, which is a fundamental step towards clinical applications.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-017-0257-6